Holme JA & Jacobsen D (1986) Mechanism of paracetamol toxicity.
Inhibition of prostaglandin synthesis in intact cells ..
This compound specifically inhibits glutathione synthesis without affecting any of the other enzyme systems pertinent to the mechanism of paracetamol toxicity (Miners et al., 1984).
What is the mechanism of absorption of paracetamol? …
The development of liver damage in mice, as indicated by elevation of alanine aminotransferase (ALAT) activity, was prevented completely by the intraperitoneal administration of L-methionine (1000 mg/kg; 6.7 mmol/kg) at the same time as oral administration of paracetamol (300 mg/kg; 1.98 mmol/kg) (Miners et al., 1984).
Update on its Analgesic Mechanism of Action
Paracetamol may be easily prepared in the laboratory by phenol with , separating the desired from the ortho- byproduct, and reducing the with . The resultant is then acetylated with . In this reaction, is strongly activating, thus the reaction only requires mild conditions (c.f. the nitration of benzene):
to be due to inhibition of prostaglandin synthesis.
Poor quality medicines do not meet official standard for strength, quality, purity, packaging and labeling. Use of counterfeit and substandard drugs bears serious health implication; such as treatment failure, adverse reactions, drug resistance, increased morbidity and mortality. In combating such type of problem studies on quality assurance take the big share. This study focus on investigation of the quality of paracetamol tablet which is registered by drug regulatory body of Ethiopia, Drug Administrative and Control Authority of (DACA) and which are not registered but marketed in Somale region of Ethiopia comparatively.