Biosynthesis of Oxytocin in the Brain and Peripheral Organs
A Synthesis of Oxytocin - ResearchGate
Each mL of Oxytocin Injection, USP (synthetic), intended for intravenous infusion or intramuscular injection, possesses an oxytocic activity equivalent to 10 USP Oxytocin Units and contains chlorobutanol (chloral derivative) 0.5%. This product may contain up to 12.5% decomposition products/impurities. Oxytocin injection (synthetic) is a sterile, clear, colorless solution of oxytocin in Water for Injection, USP prepared by synthesis. Acetic acid may have been added for pH adjustment (pH 3.0 - 5.0). The structural formula is:
Evidence for the Synthesis of Oxytocin and Vasopressin in Separate …
Oxytocin injection (synthetic) acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the tone of the uterine musculature. Synthetic oxytocin does not possess the cardiovascular effects, such as elevation of blood pressure, as exhibited by vasopressin found in posterior pituitary injection.
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It has been used in maternity wards as the drug ®, where it has been given to heavily pregnant women to induce labour. This is not as effective as natural release of oxytocin. It has now been found to have a role in the male reproductive system, being synthesised in the male testis, epididymis and prostate.
including ruminants and primates
This is different from the nucleus of a single cell.] Neurons in these hypothalamic nuclei synthesize the oxytocin precursor and package it into vesicles.
Oxytocin: The love hormone? - Medical News Today
Overdosage with oxytocin injection (synthetic) depends essentially on uterine hyperactivity whether or not due to hypersensitivity to this agent. Hyperstimulation with strong (hypertonic) or prolonged (tetanic) contractions, or a resting tone of 15 to 20 mm HO or more between contractions can lead to tumultuous labor, uterine rupture, cervical and vaginal lacerations, postpartum hemorrhage, uteroplacental hypoperfusion and variable deceleration of fetal heart, fetal hypoxia, hypercapnia or death. Water intoxication with convulsions, which is caused by the inherent antidiuretic effect of oxytocin, is a serious complication that may occur if large doses (40 to 50 milliunits/minute) are infused for long periods. Management consists of immediate discontinuation of oxytocin, and symptomatic and supportive therapy.