Oxytocin Synthesis and Oxytocin Receptor Expression …

Brodie Department of Neuroscience and Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, and Institute of Neuroscience, National Research Council, Cagliari, Italy)

The effects of oestrogen on oxytocin synthesis and release
and oxytocin receptor expression;pp.

Biosynthesis of Oxytocin in the Brain and Peripheral Organs

T1 - In vivo somatostatin, vasopressin, and oxytocin synthesis in diabetic rat hypothalamus

A Synthesis of Oxytocin - ResearchGate

Each mL of Oxytocin Injection, USP (synthetic), intended for intravenous infusion or intramuscular injection, possesses an oxytocic activity equivalent to 10 USP Oxytocin Units and contains chlorobutanol (chloral derivative) 0.5%. This product may contain up to 12.5% decomposition products/‌impurities. Oxytocin injection (synthetic) is a sterile, clear, colorless solution of oxytocin in Water for Injection, USP prepared by synthesis. Acetic acid may have been added for pH adjustment (pH 3.0 - 5.0). The structural formula is:

Evidence for the Synthesis of Oxytocin and Vasopressin in Separate …

Oxytocin injection (synthetic) acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the tone of the uterine musculature. Synthetic oxytocin does not possess the cardiovascular effects, such as elevation of blood pressure, as exhibited by vasopressin found in posterior pituitary injection.

Oxytocin injection (synthetic) is contraindicated in any of the following conditions:

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It has been used in maternity wards as the drug ®, where it has been given to heavily pregnant women to induce labour. This is not as effective as natural release of oxytocin. It has now been found to have a role in the male reproductive system, being synthesised in the male testis, epididymis and prostate.

including ruminants and primates

This is different from the nucleus of a single cell.] Neurons in these hypothalamic nuclei synthesize the oxytocin precursor and package it into vesicles.

Oxytocin: The love hormone? - Medical News Today

Overdosage with oxytocin injection (synthetic) depends essentially on uterine hyperactivity whether or not due to hypersensitivity to this agent. Hyperstimulation with strong (hypertonic) or prolonged (tetanic) contractions, or a resting tone of 15 to 20 mm HO or more between contractions can lead to tumultuous labor, uterine rupture, cervical and vaginal lacerations, postpartum hemorrhage, uteroplacental hypoperfusion and variable deceleration of fetal heart, fetal hypoxia, hypercapnia or death. Water intoxication with convulsions, which is caused by the inherent antidiuretic effect of oxytocin, is a serious complication that may occur if large doses (40 to 50 milliunits/minute) are infused for long periods. Management consists of immediate discontinuation of oxytocin, and symptomatic and supportive therapy.

Oxytocin (OT) synthesized in luteal cells is a local regulator of ovarian activity and uterine contractions.

Oxytocin synthesis and oxytocin receptor expression …

Oxytocin Injection, USP (synthetic) is indicated to produce uterine contractions during the third stage of labor and to control postpartum bleeding or hemorrhage.

et al, Role of nitric oxide on oxytocin-evoked contractions and prostaglandin synthesis in isolated pregnant rat uterus.

achieved synthesis of oxytocin in 1953 .

Oxytocin Injection, USP (synthetic) is indicated for the initiation or improvement of uterine contractions, where this is desirable and considered suitable, in order to achieve early vaginal delivery for fetal or maternal reasons. It is indicated for (1) induction of labor in patients with a medical indication for the initiation of labor, such as Rh problems, maternal diabetes, pre-eclampsia at or near term, when delivery is in the best interest of mother and fetus or when membranes are prematurely ruptured and delivery is indicated; (2) stimulation or reinforcement of labor, as in selected cases of uterine inertia; (3) adjunctive therapy in the management of incomplete or inevitable abortion. In the first trimester, curettage is generally considered primary therapy. In second trimester abortion, oxytocin infusion will often be successful in emptying the uterus. Other means of therapy, however, may be required in such cases.

T1 - The synthesis and some of the pharmacological properties of [4-L-isoleucine]-oxytocin and [4-L-leucine]-oxytocin.

Synthesis of Oxytocin in Solid Phase - YouTube

Oxytocin was discovered by a British pharmacologist named Henry Dale in 1909. It was first synthesised in 1953 by Vincent de Vigneaud (photo, left), an American chemist who was awarded the 1955 Nobel Prize for Chemistry for this discovery, the first polypeptide hormone to be synthesised. He also synthesised the related hormone vasopressin, which controls the body's retention of water. Oxytocin is , vasopressin is .