Organophosphorus reagents in organic synthesis / …

Drawbacks to the reaction are the use of toxic halogenating agents and the coproduction of organophosphorus product that must be separated from the organic product. The phosphorus reagent can be used in quantities. The corresponding alkyl bromide can also be synthesised by addition of as a source of bromide ions.

organophosphorus reagents in organic synthesis | …

button to get organophosphorus reagents in organic synthesis book ..

Organophosphorus Reagents In Organic Synthesis By Cadogan

There are numerous instances in which this reaction has been carried out in organic synthesis, and only a few representative examples are given here.

Organophosphorus reagents in organic synthesis / edited by J.I.G

Elimination of triphenylphosphine and cyclization of the ester affords coumarin derivatives (eqs 10 and 11).The reagent is sufficiently nucleophilic to be alkylated with reactive electrophiles to produce phosphorus reagents often suitable for further reactions. Hydrolysis of the triphenylphosphorus and ester moieties after alkylation affords the corresponding carboxylic acids (eq 12).Alternatively, alkylation of the phosphorane with an -halo ketone is followed immediately by elimination of triphenylphosphine to give an ,-unsaturated -keto ester. This reaction has been used in the synthesis of isocardenolides (eq 13).The ylide can be halogenated or sulfenylated to prepare more complex ylides, which can then undergo Wittig reactions to yield vinyl halides or vinyl sulfides, respectively.

Organophosphorus reagents in organic synthesis - …
Get this from a library! Organophosphorus reagents in organic synthesis. [J I G Cadogan;]

in Organophosphorus Reagents in Organic Synthesis (Ed.: J

J.I.G.: Organophosphorus Reagents in Organic Synthesis

In Organophosphorus Reagents in Organic Synthesis; Cadogan, J

Organophosphorus Reagents in Organic Synthesis, ..

Organophosphorus Reagents in Organic Synthesis