Nucleotide Variants of the BH4 Biosynthesis Pathway …
Scheme of the purine metabolismpathways, showing the position of IMPDH2, APRT and PNP in purinenucleotide biosynthesis, adopted from a previous study (35). The de novo synthesis ofpurine nucleotides begins with the phosphorylation ofribose-5-phosphate to form PRPP. In a number of reactions, PRPPcreates the first fully formed nucleotide, IMP. IMP is converted byIMPDH2 to GMP. PNP catalyzes the reversible cleavage of purinenucleosides, releasing purine nucleobases (adenine, hypoxanthine,xanthine and guanine). In the salvage pathway the free nucleobasescan be reconverted back to nucleoside-5′-monophosphates in areaction with activated sugar (PRPP) catalyzed by APRT. IMPDH2,inosine-5′-monophosphate dehydrogenase 2; APRT, adeninephosphoribosyltransferase; PNP, purine nucleoside phosphorylase;PRPP, 5-phosphoribosyl-1-pyrophosphate; IMP,inosine-5′-monophosphate; GMP, guanosine-5′-monophosphate; dADP,deoxyadenosine diphosphate; ADP, adenosine diphosphate; GDP,guanosine diphosphate; dGDP, deoxyguanosine diphosphate; AMP,adenosine monophosphate; XMP, xanthosine monophosphate.
Nucleotide Metabolism: Nucleic Acid Synthesis
KEGG PATHWAY: Metabolic pathways - Reference pathway
We examine here the biosyntheticpathways of purine and pyrimidine nucleotides and their regulation, theformation of the deoxynucleotides, and the degradation of purines andpyrimidines to uric acid and urea.
The L-Arginine-Nitric Oxide Pathway — NEJM
My salvage pathway of purine nucleotide biosynthesis include me at my computer to guarantee a happy enough as on my assignment while enjoying one language from part of it.