SOLID SUPPORTED MICROWAVE ASSISTED RAPID ..

Microwave Assisted Solid-state Synthesis, Crystal Structure, Properties of the Coordination Polymer Constructed from Tricyclohexyltin Hydroxide and o-Ferrocenylcarbonyl Benzoic Acid[J].

01 May, 2016SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF ..

Microwave‐assisted rapid and efficient functionalization of solid supports.

Microwave assisted solid-supported organic synthesis…

The chemistry for the synthesis of target compounds using microwave irradiation is established in the lab by carrying out three successive experiments post initial optimization of key parameters; to ensure process robustness. The results of these validation experiments were found to be promising, indicating its wide use for researchers. Using more advance instruments and infrastructure in Microwave assisted organic reaction enhancement (MORE); the process can be further evaluated for its scale up potential.

MICROWAVE ASSISTED ORGANIC SYNTHESIS by TIERNEY ..

The developed simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (𝛽-ethoxyethanol) were found more efficient on overall performance compare to conventional method as desired. The microwave irradiation technique led to improvement in the yield of all the target compounds with reduction in their reaction byproducts. The microwave process also substantially reduced the overall process time as expected, by reduction in reaction time against the described conventional method.

OPTIMIZATION OF MICROWAVE ASSISTED SOLVENT-FREE SYNTHESIS OF SOME SCHIFF BASES

Microwave-Assisted Organic Synthesis: A Green …

-formamides are an important class of compounds frequently used during the synthesis of biologically active compounds7, cancer chemotherapeutic agents8 and antibacterials.9 New routes to the synthesis of formamides is therefore an important area of organic chemistry. In our approach to the synthesis of these compounds primary and secondary amines were reacted with solid-supported formate under microwave conditions at 100 Watts for 30 s After filtration and removal of the solvent formamides were isolated in good yield. The results from our experiments are shown in table 3.

In addition, new instrumentation for high-throughput microwave-assisted synthesis continues to be developed at a steady pace.

Recent Trends in the Microwave-Assisted Synthesis of …

To illustrate the impact microwave assisted organic synthesis can have on chemical research, case studies drawn mainly from the pharmaceutical industry are presented.

Microwave-Assisted Synthesis of ..

In conclusion, we have developed a simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (𝛽-ethoxyethanol). The method works well for the reaction of amine and various substituted aldehydes. Because, we have synthesized imine compounds for good yields and fast reaction times in our method. Our method has some advances such as higher reaction yields, shorter reaction times, and green reaction conditions than classical requirements used of a solvent and conventional heat source (like hot plate) and other some microwave methods used of catalyst and solid supports. In addition, some Schiff bases were synthesized for the first time by us with this study.

Microwave assisted organic synthesis 1

Results: The simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (𝛽-ethoxyethanol) led to improvement in the yield of all the target compounds with reduction in their reaction byproducts & substantially reduced the overall process time as expected as compare to traditional method. Excellent isolated yields (up to 96%) were attained within short reaction times (typically, 60s) when the reaction was performed under microwaves irradiation.