01 May, 2016SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF ..
Microwave assisted solid-supported organic synthesis…
The chemistry for the synthesis of target compounds using microwave irradiation is established in the lab by carrying out three successive experiments post initial optimization of key parameters; to ensure process robustness. The results of these validation experiments were found to be promising, indicating its wide use for researchers. Using more advance instruments and infrastructure in Microwave assisted organic reaction enhancement (MORE); the process can be further evaluated for its scale up potential.
MICROWAVE ASSISTED ORGANIC SYNTHESIS by TIERNEY ..
The developed simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (𝛽-ethoxyethanol) were found more efficient on overall performance compare to conventional method as desired. The microwave irradiation technique led to improvement in the yield of all the target compounds with reduction in their reaction byproducts. The microwave process also substantially reduced the overall process time as expected, by reduction in reaction time against the described conventional method.
Microwave-Assisted Organic Synthesis: A Green …
-formamides are an important class of compounds frequently used during the synthesis of biologically active compounds7, cancer chemotherapeutic agents8 and antibacterials.9 New routes to the synthesis of formamides is therefore an important area of organic chemistry. In our approach to the synthesis of these compounds primary and secondary amines were reacted with solid-supported formate under microwave conditions at 100 Watts for 30 s After filtration and removal of the solvent formamides were isolated in good yield. The results from our experiments are shown in table 3.