including those associated with the synthesis of DNA and RNA.

• Ribosomes require magnesium in order to maintain their physical stability: their aggregation into polysomes which can form peptide chains is possible only in the presence of Mg2+. During magnesium deficiency they dissociate into small particles. The almost exclusive function of ribosomes is the biosynthesis of proteins. The stabilizing activity of magnesium on polysomes maintains the structure of RNA complexes, allowing, with the help of elongation factors (188, 473) and polyamines (1149), the formation of polypeptides and ultimately the most stable conformation of the protein (12, 13, 14, 323, 546, 549, 1327).

What Is the Role of RNA in Protein Synthesis

In the lungs, magnesium participates in the synthesis of surfactant (1100).

This lesson discusses the role of RNA in protein synthesis

Magnesium chloride solutions offer a medical miracle to humanity, one that many have sought but have not found. In fact Dr. Carolyn Dean, titled her book The Magnesium Miracle and she could not have been more correct. Nothing short of a miracle is to be expected with increases in the cellular levels of magnesium if those levels have been depleted.

Magnesium pemoline: Lack of effect on brain RNA …

Thus, in the absence of Mg(++), DNA, tRNA, and rRNA were synthesized in the same relative proportions as during exponential growth, at rates close to one-half the instantaneous rates of synthesis in the bacteria growing exponentially at the start of starvation.

After the first few hours, this rate was constant, the amount of RNA present at the start of Mg(++) starvation being synthesized about every 120 min.
Effects of magnesium deficiency on protein and nucleic acid synthesis in vivo

And magnesium is required for ATP synthesis in brain cells.

In fact, hypersecretion of PTH is actually observed, both in animals and in humans (570, 732, 950, 1055, 1187, 1352). Hyposecretion of CT is very difficult to discover because of the limited sensitivity of techniques for measuring this hormone. It is consistent that it has been described recently in the spasmophilic form of magnesium deficit (893, 1264). On the other hand, an increase in 1,25-(OH)2D does not seem to be involved; it is not normally observed in experimental animals or in humans during magnesium deficit (361, 398, 783, 902, 903, 1062, 1371). These normal levels of l,25-(OH)2D, seemingly inappropriate in hypocalcemia, may be caused by the effect of antagonists on vitamin synthesis. The direct cellular effects of magnesium deficit on the hepatic and renal tissues in which the magnesium-dependent steps of the hydroxylations that activate vitamin D occur should tend to reduce the synthesis of 1,25-(OH)2D as has actually been observed in vitro (903, 1062). On the contrary, various general and humoral effects may combine to stimulate the synthesis of vitamin D, whether it be insulin (361, 396, 398), hyperparathyroidism or hypophosphatemia (641). The digestive hormones may also participate in remedying calcium problems secondary to magnesium disturbances. VIP (vasoactive intestinal polypeptide) and CEP (calcium elevating peptide) are two hormones capable of increasing blood calcium levels and it is possible that magnesium is involved in the secretion of digestive hormonal peptides (25, 742, 821, 1121). An increase in thyroxin (T4) has been considered as a protective clement against nephrocalcinosis (1281), but its many harmful effects, especially an increased urinary clearance of magnesium, prevent its being considered as a regulatory factor (732). One should note that we are not referring here to studies of magnesium deficiencies in rats, the only animal to develop hypercalcemia in such cases (669, 732). In this species the intervention of the PTH-CT system works in the opposite direction; one observes a lowering of PTH and an increase in CT (732, 1224).

Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis

phage polymerase binds and initiates RNA synthesis.

It may be noted that having adequate magnesium levels (i.e., magnesium sufficiency) does not prevent the synthesis of cholesterol needed for health (e.g., inactivated HMG-CoA reductase can be reactivated by other enzymes, some of which require magnesium for proper function). Yet, by selectively inhibiting the enzyme HMG-CoA reductase, magnesium-ATP complex can prevent the overproduction of cholesterol, a known risk factor in cardiovascular health conditions. Moreover, through its role in reducing homocysteine levels, magnesium helps prevent the oxidation of cholesterol. Oxidized cholesterol is a major problem for cardiovascular health. Given that magnesium both regulates synthesis of cholesterol itself and reduces levels of the amino acid homocysteine (thereby lowering the oxidation of cholesterol), magnesium may be regarded as an essential nutrient for optimal health of the cardiovascular system. Magnesium inhibits oxidation and overproduction of cholesterol--naturally! It works around-the-clock to support your heart’s health. In fact, this “must have” heart-healthy mineral helps ensure the best health for your entire cardiovascular system

01/05/2000 · Numerous enzymes associated with DNA and RNA synthesis are also zinc ..

for the storage of energy within cells and the synthesis of RNA

• Enzymes of nucleic acid and protein metabolism (188, 328, 684, 690, 732, 1149, 1327): RNA polymerase which allows the synthesis of RNA and especially that of messenger RNA which, associated with post-ribosomal factors of initiation and elongation and with polyamines, codes for amino acids to produce specific proteins; DNA polymerase which allows the reconstitution and recombination of DNA, ornithine carbamyl transferase, glutamine synthetase, carbamate kinase, argininosuccinate synthetase, creatine kinase, insulinase, leucine aminopeptidase which appears to be similar to hypertensinase....