Lumefantrine synthesis essay - American Sierra Gold

Rezatrin Forte (Artemether/Lumefantrine) is used to treat acute malaria. Both its active ingredients work differently to block the synthesis of protein by the parasites and treat the infection.

Lumefantrine is a synthetics amino ..

Both artemether and lumefantrine were shown to inhibit nucleic acid and protein synthesis

Lumefantrine is a synthetic racemic flourine mixture

Rezatrin Forte (Artemether/Lumefantrine) is used to treat acute malaria. Both its active ingredients work differently to block the synthesis of protein by the parasites and treat the infection. Medical experts believe that lumefantrine works by blocking the production of B-hematin. The other ingredient (artemether) is metabolized into its active form diydroartemisnin upon ingestion, and it acts on the malarial parasites, attacking the blood schizonts. As a result of this, the parasites that cause the infection are destroyed.

Lumefantrine (or benflumetol) is an antimalarial drug

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

Both artemether and lumefantrine inhibit nucleic acid and protein synthesis
Solvent-less Synthesis, Antimalarial and Toxicity Evaluation of Lumefantrine-Copper Complex in Swiss Mice

Streamlined Process for the Conversion of Artemisinin …

Coartem Tablets, a fixed ratio of 1:6 parts of artemether and lumefantrine, respectively, is an antimalarial agent. Artemether is rapidly metabolized into an active metabolite dihydroartemisinin (DHA). The antimalarial activity of artemether and DHA has been attributed to endoperoxide moiety. The exact mechanism by which lumefantrine exerts its antimalarial effect is not well defined. Available data suggest lumefantrine inhibits the formation of β-hematin by forming a complex with hemin. Both artemether and lumefantrine were shown to inhibit nucleic acid and protein synthesis.

Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine.

for the Conversion of Artemisinin to Artemether

Title of Invention: PROCESS FOR THE SYNTHESIS OF LUMEFANTRINE: Abstract: Disclosed herein is an improved process for the synthesis and purification of …

The drug works against the erythrocytic stages of P