Fatty Acid Synthesis | Lipoprotein | Triglyceride
01/01/1999 · Basic Med Biochem.I
Methods and Results-In 24-hour fasted mice, Angpt14 overexpression increased plasma triglycerides (TG) by 24-fold, which was attributable to elevated VLDL-, IDL/ LDL-and HDL-TG content. Angpt14 overexpression decreased post-heparin LPL activity by stimulating conversion of endothelial-bound LPL dimers to circulating LPL monomers. In fasted but not fed state, Angpt14 overexpression severely impaired LPL-dependent plasma TG and cholesteryl ester clearance and subsequent uptake of fatty acids and cholesterol into tissues. Consequently, hepatic cholesterol content was significantly decreased, leading to universal upregulation of cholesterol and fatty acid synthesis pathways and increased rate of cholesterol synthesis.
Association Mapping and Marker Development of …
Triglycerides made up oflong chain fatty acids, in the form of chylomicrons (from intestinalabsorption) or lipoproteins (from hepatic synthesis), are hydrolyzedto glycerol and free fatty acids by an enzyme called lipoproteinlipase (LPL).