of chemically modified lignite and polyethylene glycol)

Founded in 2004 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

Synthesis of Polyethylene Glycol ..

J., Characterization of poly(ethylene glycol) hydrogels formed via click chemistry.

A facile synthesis of branched poly(ethylene glycol) ..

We synthesized a library of 50 poly(ethylene glycol) (PEG) derivatives to expand the extent of conjugation with biologically active molecules (biopolymers, peptides, drugs, etc.) and biomaterial substrates. The formation of PEG derivatives was confirmed with HPLC, 1H and 13C NMR. PEG derivatives were polymerized into networks in order to study the role of PEG and terminal functional groups in modulating the hydrophilicity of biomaterials and cell−biomaterial interaction. The resulting surface hydrophilicity and the number of adhered fibroblasts were primarily dependent on the PEG concentration with the molecular weight and the terminal functional group of PEG derivatives being less important. One of PEG derivatives, PEG−bis-glutarate, was utilized to link peptide sequences to gelatin backbone in the formation of novel biomedical hydrogels. PEG−peptide conjugates were characterized by mass spectroscopy. PEG−peptide modified gelatins were characterized by gel permeation chromatography.

Synthesis of Poly(ethylene glycol) Derivatives

Yamada, Kohzo Ito, and Hideaki Yokoyama, "Inclusion Complex of α-Cyclodextrin with Poly(ethylene glycol) Brush", Macromolecules, 49(18), 6947-6952(2016).

R., Glycosylthiomethyl Chloride: A New Species for -Neoglycoconjugate Synthesis.

synthesis and characterization of poly ..

JenKem Technology manufactures high quality reactive polyethylene glycol derivatives (activated PEG products) with high purity and narrow polydispersity, from small non-GMP laboratory scale to commercial scale in GMP and non-GMP grade.

Other dichloro derivatives of ethylene oxide can be ..

We synthesized a library of 50 poly(ethylene glycol) (PEG) derivatives to expand the extent of conjugation with biologically active molecules (biopolymers, peptides, drugs, etc.) and biomaterial substrates. The formation of PEG derivatives was confirmed with HPLC, 1H and 13C NMR. PEG derivatives were polymerized into networks in order to study the role of PEG and terminal functional groups in modulating the hydrophilicity of biomaterials and cell−biomaterial interaction. The resulting surface hydrophilicity and the number of adhered fibroblasts were primarily dependent on the PEG concentration with the molecular weight and the terminal functional group of PEG derivatives being less important. One of PEG derivatives, PEG−bis-glutarate, was utilized to link peptide sequences to gelatin backbone in the formation of novel biomedical hydrogels. PEG−peptide conjugates were characterized by mass spectroscopy. PEG−peptide modified gelatins were characterized by gel permeation chromatography.

Find Glycol Synthesis Polyethylene related suppliers, ..

Pharmaceutical chemistry is becoming increasingly complex with multi-step processing, where the product from one step becomes a starting material for the next step, until the finished drug product is synthesized. Bulk chemicals which are intermediates of the finished product may be transferred between organic synthesis plants for various technical, financial and legal considerations. Most intermediates and products are produced in a series of batch reactions on a campaign basis. Manufacturing processes operate for discrete periods of time, before materials, equipment and utilities are changed to prepare for a new process. Many organic synthesis plants in the pharmaceutical industry are designed to maximize their operating flexibility, due to the diversity and complexity of modern medicinal chemistry. This is achieved by constructing facilities and installing process equipment that can be modified for new manufacturing processes, in addition to their utility requirements.

polyethylene glycol , synthesis .

In the plastics industry, ethylene glycol is an important precursor to polyester fibers and resins. Polyethylene terephthalate (PET) resins used to make plastic bottles for soft drinks is prepared from the reaction of ethylene glycol with terephthalic acid.

The branched PEG and its derivatives were characterized by SEC, ..

Founded in 2004 by recognized experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to on-site manufacturing from ethylene oxide, enabling facile traceability for GMP regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.