the hydrazine of isonicotinic acid (INH), ..

INH inhibits the synthesis of mycolic acids in all strains but mycolic acid production in resistant strains continues. Quemard et al. [] and Hanoulle et al. [] showed that in the existence of ETH, mycolic acid synthesis of the resistant and susceptible mycobacteria is damaged. Due to the resistance problems of MDR-TB, second line drugs such as ethionamide (ETH) with lower activity or increased toxicity are used. ETH affects the biosynthesis of mycolic acids by inhibiting NADH specific enoyl-acyl carrier protein reductase.

(INH), is an antibiotic used ..

the enzyme responsible for the rate-limiting step in heme synthesis

Isoniazid (Isonicotinic Acid Hydrazide; INH) …

Isoniazid (isonicotinic acid hydrazide [INH]) is an antimicrobial that has been used as a first-line agent for prophylaxis and treatment of tuberculosis since 1952. Patients with a recently positive purified protein derivative (PPD) skin test and normal chest radiograph findings routinely are given a 6- to 9-month course of INH. Patients with active disease are put on a regimen of INH combined with other antituberculous medications. Because of errors in dosage or intentional overdose, life-threatening toxicity may result.

Professional guide for Isoniazid (Isonicotinic Acid Hydrazide; INH)

Isoniazid binds to pyridoxal-5-phosphate, the active form of pyridoxine (vitamin B-6), to form INH-pyridoxal hydrazones. Pyridoxal-5-phosphate is a cofactor for glutamic acid decarboxylase and GABA transaminase in the GABA synthetic pathway. INH overdose results in decreased pyridoxal-5-phosphate, decreased GABA synthesis, increased cerebral excitability, and seizures. Co-ingestion of ethanol potentiates toxicity by enhancing degradation of phosphorylated pyridoxine.

23/09/2008 · Química Nova Print version ISSN ..

Mastering Micro Ch. 33 Flashcards | Quizlet

globular proteins of the cell membrane.

Effect of heme on globin messenger RNA synthesis