(INH), is an antibiotic used ..
Isoniazid (Isonicotinic Acid Hydrazide; INH) …
Isoniazid (isonicotinic acid hydrazide [INH]) is an antimicrobial that has been used as a first-line agent for prophylaxis and treatment of tuberculosis since 1952. Patients with a recently positive purified protein derivative (PPD) skin test and normal chest radiograph findings routinely are given a 6- to 9-month course of INH. Patients with active disease are put on a regimen of INH combined with other antituberculous medications. Because of errors in dosage or intentional overdose, life-threatening toxicity may result.
Professional guide for Isoniazid (Isonicotinic Acid Hydrazide; INH)
Isoniazid binds to pyridoxal-5-phosphate, the active form of pyridoxine (vitamin B-6), to form INH-pyridoxal hydrazones. Pyridoxal-5-phosphate is a cofactor for glutamic acid decarboxylase and GABA transaminase in the GABA synthetic pathway. INH overdose results in decreased pyridoxal-5-phosphate, decreased GABA synthesis, increased cerebral excitability, and seizures. Co-ingestion of ethanol potentiates toxicity by enhancing degradation of phosphorylated pyridoxine.