Protein synthesis inhibitor - Wikipedia
Protein synthesis Inhibitors - LKT Labs
Erythromycin inhibits protein biosynthesis in ribosomes (mitoribosomes) located within the mitochondrion of the yeast cell, which results in a disruption of cytochrome biosynthesis with an adverse effect on respiration.
Protein Synthesis Inhibitors Flashcards | Quizlet
Definitely a good product review, but also very well structured from scientific point of view. Good references also. Will use it as a source for my next post about the different protein synthesis inhibitors.
Antibiotic Inhibition of Protein Synthesis
An ATP-peptide conjugate was synthesized as a bisubstrate analogue inhibitor of the serine/threonine kinase protein kinase A. The compound was found to be a linear, competitive inhibitor with respect to ATP substrate, exhibiting a Ki of 3.8μM. The compound was noncompetitive with respect to peptide substrate. The inhibitor was shown to be selective for protein kinase A versus the closely related protein kinase C as well as tyrosine kinase Csk. This analysis provides new evidence for the dissociative transition state of protein serine/threonine kinases and illustrates a simple method to convert a low affinity peptide substrate to a selective and moderately potent inhibitor for these enzymes.
 Shiga toxin as inhibitor of protein synthesis
Biological Role(s): DNA synthesis inhibitor Any substance that inhibits the synthesis of DNA. protein synthesis inhibitor A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein. bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. antibiotic A substance that is biostatic or biocidal at low concentrations towards bacteria, yeasts, moulds, or other form of life, especially pathogenic or noxious organisms. Although the term was originally restricted to substances produced by microorganisms, its use was later expanded to include derivatives of such substances and it is now commonly used to include entirely synthetic compounds. (via heterocyclic antibiotic )