Enzyme induction screen for ergosterol biosynthesis inhibitors
Ergosterol biosynthesis inhibitors become fungicidal …
The test method used to study ergosterol biosynthesis in the wild-type isolate W 5 could also be applied to DMI-resistant isolates E 300-3 , HP and I 33 , It was noted that the quality of cell-free extracts of wild-type and resistant isolates differed slightly.
for inhibition of ergosterol biosynthesis relates ..
IC values (concentrations which inhibit incorporation of radioactivity into ergosterol by 50%) of the highly toxic DMI fungicides imazalil, itraconazole, ketoconazole, penconazole and propiconazole ranged from 6.5 ± 0.5 x 10 -9to 1.7 + 0.7 x 10 -11M.
Gyne-Lotrimin 3 Drug Information
1961, 83, 3080) made the first total synthesis of arachidonic acid.
Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().
Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().
Bremer J et al.
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discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().
Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().
First demonstration of the biosynthesis of vitamin A from
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For example, in fluconazole-susceptible C. albicans fluconazole only partially inhibits ergosterol and completely blocks obtusifoliol synthesis, whereas voriconazole completely inhibits both ergosterol and obtusifoliol synthesis 5. Itraconazole and fluconazole may also inhibit 3-ketoreductase, which catalyzes the reduction of the 3-ketosteroid obtusifolione to obtusifoliol in C. neoformans 6.