Inflammation and endometrial cancer: a hypothesis.
Obesity, inflammatory markers, and endometrial cancer …
Chronic inflammation may play an etiologic role in ovarian and endometrial cancer, and it is hypothesized that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of developing these malignancies. No prospective study with a large multiethnic population has explored this hypothesis.
Obesity, inflammatory markers, and endometrial cancer risk: ..
Chronic inflammation has been postulated to contribute to ovarian and endometrial carcinogenesis through various pathophysiological pathways (–). Chronic inflammation, including elevations in cytokines, prostaglandins and cyclooxygenase (COX) with concomitant oxidative stress, induces rapid cell division and DNA damage which increase the risk of malignancy (). Specific exposures, such as perineal talc use or medical conditions associated with inflammation, including endometriosis and pelvic inflammatory disease, have been reported to increase ovarian cancer risk (–). Elevated serum levels of C-reactive protein, a biological marker of chronic systemic inflammation, has likewise been associated with increased risk of ovarian and endometrial cancers (–). These epidemiologic observations are supported by in vitro studies showing that aspirin and other analgesic drugs with anti-inflammatory properties inhibit tumor growth and induce apoptosis in ovarian and endometrial cancer cell lines (–).