KW - maximum entropy production
KW - Proportionality Hypothesis
The International Consortium for Blood Pressure (ICBP) performed a multi-stage GWAS meta-analysis of blood pressure and hypertension in > 20,000 individuals of European ancestry. Phenotypes included in the analysis were systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP, the difference between SBP and DBP), mean arterial pressure (MAP, a weighted average of SBP and DBP) and hypertension.
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In 1994, Reed Wickner of the National Institutes of Health made a key observation: the bizarre yeast trait appeared at a higher frequency when URE2 was overexpressed. He further determined that the Ure2 proteins specifically, rather than the DNA and RNA molecules encoding them, were responsible for this effect. Wickner then offered the only explanation compatible with the seemingly incongruous results: the information responsible for the trait’s inheritance was encoded by an alteration in the Ure2 protein itself. In other words, Ure2 forms a prion, which reproduces itself through the conversion of other Ure2 molecules in the cytoplasm. During cell division, the prion particles divide among daughter cells, thereby perpetuating the trait in a non-Mendelian manner. (See .)
QN chapter 7 Flashcards | Quizlet
In another study, Kato et al. conducted a meta-analysis of GWAS of SBP and DBP in >19,000 subjects of east Asian ancestry from the AGEN-BP consortium, followed by independent replications in east Asian samples.
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In 2012, the CARDIoGRAMplusC4D Consortium performed an association analysis in 63,746 coronary artery disease (CAD) cases and 130,681 controls of European or Asian descent, and identified 15 loci reaching genome-wide significance. The total number of susceptibility loci for CAD returned by this analysis was 46, and a further 104 independent variants were found to be strongly associated with CAD at a 5 % false discovery rate (FDR).