by Brønsted acids with Hantzsch esters ..

Due to the growing interest in marine alkaloids, a detailed discussion of select, newly developed one-pot methodologies that have been utilized for the modification of marine alkaloids or the synthesis of common alkaloid moieties emphasizing asymmetric synthesis, are presented here. This mini-review discusses applications, mechanistic insights and enantioselectivity of recently developed one-pot methods that have been published during 2009. Those reports that could be applied in the synthesis of marine alkaloid scaffolds (i.e., alkaloid moieties found in marine alkaloids) are emphasized. This mini-review will also cover our results for the manzamine alkaloids, as well as detailed asymmetric one-pot methods for the synthesis of substituted piperidines, quinolizidines, pyrrolidines, hexahydropyrrolizines, octahydroindolizines and γ-lactams.

Synthesis of aminothiazoles via the Hantzsch method Glaxo-Wellcome ..

(1953) Colorimetric estimation of formaldehyde by means of theHantzsch reaction.
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of the method to parallel synthesis, ..

4 Microwave heating technique applied to high throughput, automated, one step, parallel synthesis of diverse substituted pyridines using Hantzsch protocol

Synthesis of aminothiazoles via the Hantzsch method

5 (a) Solid-phase solid state synthesis of N-alkyl imides from anhydrides, (b) Combs reported copper (II) mediated N-arylation of the benzimidazole with -tolboronic acid, the first example of MICROCOS for N-arylated heterocycles, (c) Microwave-assisted heating technique is suitable for the conversion of iodides to nitriles and subsequently tetrazole

TheseUgi reactions, using clay as inorganic support are suitable for high speedparallel synthesis and library generation (Figure 7e).
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Dihydropyridine C-Glyconjugates by Hantzsch Cyclocondensation

Use of products containing formaldehyde in medicinal and other technical areasa-------------------------------------------------------------------------Area Use ------------------------------------------------------------------------- Detergents and cleaning Preservative in soaps, detergents, cleaning agents industry agents Cosmetics industry Preservative in soaps, deodorants, shampoos, etc; additive in nail hardeners and products for oral hygiene Sugar industry Infection inhibitor in producing juices Medicine Disinfection, sterilization, preservation of preparations Petroleum industry Biocide in oil well-drilling fluids; auxiliary agent in refining Agriculture Preservation of grain, seed dressing, soil disinfection, rot protection of feed, nitrogen fertilizer in soils, protection of dietary protein in ruminants (animal nutrition) Rubber industry Biocide for latex; adhesive additive; anti- oxidizer additive also for synthetic rubber Metal industry Anti-corrosive agent; vehicle in vapour depositing and electroplating processes Leather industry Additive to tanning agents Food industry Preservation of dried foods; disinfection of containers; preservation of fish and certain oils and fats; modifying starch for cold swelling Wood industry Preservative Photographic industry Developing accelerator; hardener for gelatin layers -------------------------------------------------------------------------a Modified from: BASF (1984).

A One-Pot Parallel Reductive Amination of Aldehydes …

A sensitive method for the determination of formaldehyde is basedon the Hantzsch reaction between acetylacetone (2,4-pentanedione) am-monia and formaldehyde to form 3,5-diacetyl-1,4-dihydrolutidine.

One-Pot Parallel Synthesis of ..

In this mini-review, we have highlighted a number of one-pot asymmetric methodologies developed for the synthesis of important alkaloid moieties. One-pot reactions are highly practical and ideal for scaling drug leads to gram scale and greater. The manzamine alkaloids are still providing inspiration for new chemistry in which one-pot methodologies are being developed and will be discussed in separate reports. We anticipate a greater application of these methods and similar methodologies in the field of total synthesis of marine alkaloids and have highlighted the possible route to the schulzenine alkaloids. Two or more methodologies could be combined to design a complete synthesis of a particular target. The alkaloid moieties highlighted in this mini-review (i.e., substituted piperidines, quinolizidines, pyrrolidines, hexahydropyrrolizines, octahydroindolizines and γ-lactams) are common within the alkaloid family. Although there are many methods for the synthesis of these moieties, the development of one-pot methodologies to obtain high yields with a high degree of enantioselectivity will provide numerous opportunities for the synthetic community.

Catalyst-Free Reduction of Aldimines with Hantzsch …

In: Scientific reviews of soviet literature on toxicity and hazards of chemicals, Moscow, Centrefor International Projects, GKNT, 20 pp (Report No.