for the biosynthesis of the surface glycerolipid polymer cutin ..

Alkyl DHAP synthase Nature of lipids synthesized in peroxisomes Export of lipid intermediates from peroxisomes Physiological significance of lipid biosynthesis in peroxisomes Conclusions References ABBREVIATIONS Dihydroxyacetone phosphate Dihydroxyacetone phosphate acyltransferase e.r.

The Role of Phosphatidate Phosphatase in Glycerolipid Biosynthesis

Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.

intermediates of glycerolipid biosynthesis

discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().

Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().

First demonstration of the biosynthesis of vitamin A from

Topic 8 Fatty Acid Biosynthesis for Fuels Flashcards | …

1961, 83, 3080) made the first total synthesis of arachidonic acid.

Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().

Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().

Bremer J et al.

Glycerolipid biosynthesis in peroxisomes via the acyl dihydroxyacetone phosphate pathway.

17/11/2014 · Glycerolipid biosynthesis in plants ..

Tritium isotope effects in the measurement of the glycerol phosphate and dihydroxyacetone phosphate pathways of glycerolipid biosynthesis in rat liver.

The involvement of glycerolipid pathway ..

The glycerol portion of lipids may be derived biosynthetically by reduction of dihydroxyacetone phosphate to glycerolphosphate, and then be acylated with fatty acids or, alternatively, dihydroxyacetone phosphate may first be acylated and then reduced to 1-acyl sn glcerol-3-phosphate. Since the former pathway utilizes NADH for reduction of the C-2 carbonyl, while the latter requires NADPH, we were able to compare the relative participation of the two pathways for phospholipid synthesis by measuring the incorporation of radioactivity from tritiumlabeled NADH and NADPH into C-2 of lipid glycerol. The acyl-dihydroxyacetone phosphate pathway plays a significant role in glycerolipid synthesis in mouse liver homogenates and a clearly dominant one in Ehrlich ascites tumor cell homogenates. This finding is related to a reported lack of glycerol-3-phosphate dehydrogenase in tumor cells and to their high glycerol ether lipid content.

(1982), GLYCEROLIPID BIOSYNTHESIS IN PEROXISOMES VIA THE ACYL DIHYDROXYACETONE PHOSPHATE PATHWAY

in glycerolipid biosynthesis, ..

demonstrated that nearly allphosphatidylserine and a minimum of 70% of phosphatidylethanolamine is on theinside surface of the human erythrocyte membrane, thus "presenting a strongevidence for an asymmetric arrangement of phospholipids" ().

First demonstration of an inhibition of sterol biosynthesis (HMG-CoA reductaseactivity) by oxygenated derivatives of cholesterol in cultured mammalian cells ().

For the first time, the existence of polyunsaturated fatty acids was reported inmarine bacteria ().

Synthesis of Eicosanoids, Glycerolipids and Isoprenoids - Glycerolipid Biosynthesis.

and suggests the secretory pathway is ..

Our research has explored the mechanics and function of a phospholipid called acyl dihydroxyacetone phosphate (acyl DHAP). Our work has revealed that acyl DHAP plays a notable role in cell physiology and certain genetic disorders with far-reaching implications for human and animal biology. Our studies on the metabolism of acyl DHAP led to the discovery of a new lipid biosynthetic pathway, a novel biochemical reaction for the synthesis of ether bond in lipids, an unexpected subcellular site (peroxisomes) for lipid biogenesis in cells and the nature of biochemical defects in a number of genetic diseases involving peroxisomal disorders.

(2002) Peroxisomal acyl dihydroxyacetone phosphate pathway for glycerolipid biosynthesis

Bayberry ( Myrica pensylvanica ) ..

first demonstrates the reliability of a new stratigraphictechnique for climatic assessment utilizing the relative abundance of two C37alkenones in marine sediments ().

First demonstration of a specific receptor-mediated release of 20:4n-6 and22:6n-3 from plasmalogen phospholipids ().

Evidence is given that phosphatidic acid is a lipid second messenger with growthfactor-like properties, stimulating the breakdown of phosphoinositides andcalcium release ().

Demonstration of an inhibition of protein kinase C by sphingosine whichsuggested an important role for that lipid in the regulation of the signaltransduction pathways (, ).

First clear demonstration of a formation of diacylglycerol as second messengerfrom phosphatidylcholine in hormone-stimulated cells ().

Abscisic acid, one of the most important phytohormones, has been shown to bepresent in the central nervous system of pigs and rats ().

After the discovery of 20:5n-3 in a marine bacterium (Johns RB et al., 1977), a study on 11 piezophilic bacteria (from 1200 to 10 476 m of sea depth) revealed they produced EPA (20:5n-3) and DHA (22:6n-3) in increasing proportion oftotal fatty acids when pressure increased ().