Flavanoid biosynthesis in Camellia sinensis
Synthesis of Chalcone and Flavanone Compound Using …
Inhibition of DENV2 protease activities by two classes of natural products, the flavanones and chalcone extracted from an Asian fingerroot has been reported in an earlier study (). The bioactive natural products from the study are used as a template to design and synthesis new compounds that could possess inhibitory property toward dengue virus infection. The antiviral activity of these synthesized compounds was established in this study employing the cell culture system which reflects the virus-host interaction toward any effectors.
Organic Chemical Synthesis (BINOL, flavanoid, chalcones, ..
General procedure for synthesis of Flavanones and Aryl chalcones by microwave: 2.5 mmole of Hetero Aldehyde/Aryl Aldehyde and 2.5 mmole of 2-hydroxy-4-substituted acetophenone were taken in 250ml RBF. 20 ml Ethanol and 0.1 mole of Potassium hydroxide were added in same RBF. The RBF was kept in Microwave at low voltage for 2-8 min. The reaction was moniterd by TLC. Ethanol was evaporated and solid washed with cold water. Recrystallized from Methanol.
ChemInform Abstract: Synthesis and Antioxidant Activity …
ABSTRACT: Flavanoids are plant secondary metabolites, synthesized by microwave assisted synthesis and green chemistry approach since, the conventional method of synthesis uses various organic solvents, hazardous by product, tedious work that requires more reaction time. Flavonoids have general structure of 15-carbon skeleton which consists of two phenyl ring (A and B) and heterocyclic pyran ring(C). Flavones are one of the important class of flavanoids acquires a broad spectrum of activity. Chalcone (1, 3-diaryl-2-propen-1-ones), is a privileged structure, demonstrating promising anti-microbial, anti-inflammatory and anticancer activities. The basic moiety of flavanoids gives numerous biological activities henceforth; flavanoid and chalcone derivatives were synthesized and confirmed by physiochemical and spectral data. Biological screening was done for antibacterial especially for anti-methicillin resistant Staphylococcus aureus and antifungal screening with using standard drug Ofloxacin and Griseofulvin respectively. Compound NKP-3, NKP-4, NKP-8a, NKP- 9a and NKP-10a are more active and other compounds are less active against bacteria and fungi.