to prevent the peripheral synthesis of dopamine from L-DOPA
F dopa synthesis essay - GRC Surgical
TRIUMF’s nuclear-medicine group and its partners are working with L-DOPA and F-DOPA in aid of Parkinson’s research, and recently have started investigating its role in diagnosis of patients with neuroendocrine tumours.As well as being taken up by certain normal tissues within the body, F-DOPA also accumulates within neuroendocrine tumours (neoplasms which originate from the fetal neuroectoderm and contain secretory granules), including adrenal lesions such as phaeochromocytomas and paragangliomas. As a consequence of its radioactive decay, the F-18 atom attached to the DOPA molecule permits precise location of the tumours using a PET/CT scanner (see Figure 1).The synthetic organic chemistry performed to add the Fluorine-18 isotope can be done in only a limited number of places, including BC Cancer Agency and TRIUMF.
Dopamine Synthesis Capacity Before Onset of …
The following review outlines the developments in the field of [18F]F-DOPA radiosyntheses via electrophilic synthesis routes and the more recent synthesis improvements via nucleophilic syntheses. The main focus of this work is to compare the radiochemical yields (RCYs), radiochemical purities (RCPs), enantiomeric excess (ee), synthesis times, reliability, and a potential for automation of the different radiosynthesis pathways.