When DNA replication and protein synthesis come …
Meindert Lamers (Leiden University Medical Center)
'STRUCTURAL FEATURES OF HIGH FIDELITY DNA REPLICATION'
Susan Lees-Miller (Arnie Charbonneau Cancer Institute)
'NON-REPAIR FUNCTIONS OF DNA-PKcs'
Karolin Luger (University of Colorado at Boulder)
'POLY (ADP-RIBOSE) POLYMERASE 1 IN DNA DAMAGE RECOGNITION'
Mauro Modesti (Cancer Research Center of Marseille)
'DYNAMICS AND MECHANICS OF DNA TETHERING BY CORE c-NHEJ FACTORS AND BY THE MRE11/RAD50/NBS1 COMPLEX'
Zachary Nagel (Harvard University)
'COMPREHENSIVE ANALYSIS OF DNA REPAIR CAPACITY IN NORMAL AND CANCEROUS CELLS'
Mark O'Connor (AstraZeneca)
'TARGETING THE REPLICATION STRESS RESPONSE IN CANCER'
John Pascal (Université de Montréal)
'STRUCTURAL BIOLOGY OF POLY(ADP-ribose) POLYMERASE ENZYMES'
Tanya Paull (University of Texas at Austin)
'THE Mre11-Rad50-Nbs1 COMPLEX AND REGULATION OF DNA REPAIR'
Phoebe Rice (University of Chicago)
'AN MCM-RELATED HELICASE AND OTHER REPLICATION-RELATED MACHINERY FOUND ON THE MOBILE ELEMENT BEHIND THE MRSA EPIDEMIC'
Andrej Sali (University of California, San Francisco)
'INTEGRATIVE STRUCTURE MODELING OF DNA-PKcs'
Orlando Scharer (Ulsan National Institute of Science and Technology)
'REPLICATIVE AND TRANSLESION SYNTHESIS DNA POLYMERASES IN ICL REPAIR'
Katharina Schlacher (MD Anderson Cancer Center)
'RAD51C IN DNA FORK PROTECTION AND STABILITY'
David Schriemer (University of Calgary)
'PROTEOMICS-GRADE STRATEGIES FOR INTEGRATIVE STRUCTURAL BIOLOGY'
Titia Sixma (NKI)
'STRUCTURAL BIOLOGY OF DNA MISMATCH REPAIR'
Maria Spies (University of Iowa)
'INHIBITORS OF THE RAD52-ssDNA INTERACTION'
Terence Strick (Institut Jacques Monod)
'SINGLE-MOLECULE ANALYSIS OF MULTICOMPONENT DNA REPAIR SYSTEMS'
Madalena Tarsounas (The CR-UK/MRC Oxford Institute for Radiation Oncology)
'WNT/b-CATENIN SIGNALING IN BRCA-DEFICIENT CELLS'
Dna replication and protein synthesis - …
Unit 5: DNA Replication and Protein Synthesis - Welcome …
The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, template-switching, R-loop resolution, gap-filling, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.
What surprised you about DNA replication and protein synthesis
Hair grows from your head, nonstop, day in and day out. The cells of your hair follicles somehow generate all of the protein that make up this hair. How is this protein created? The answers to these questions are DNA replication and protein synthesis. The activity in this section places you within the cell, involving you with the processes of DNA replication and protein synthesis.