Many medical conditions reflect a disorder of a protein's ..
Protein recognition and disorder: a debate - Nanowerk
Proteins are large, exquisitely folded molecules that play essential and diverse roles in all living organisms. Proteins must achieve and retain a specific 3-dimensional conformation in order to function properly. If protein folding is disrupted, proteins can display sticky surfaces and aggregate through several stages eventually assembling into fibers (shown below), and such nonfunctional protein aggregates can be toxic. Protein misfolding diseases are found in multiple organs, and can be defined histopathologically by the presence of specific misfolded protein(s) deposits.
Protein recognition and disorder: a debate (Nanowerk News) ..
"We used a mouse model in which a key gene controlling initiation of protein synthesis was deleted. In these mice, production of neuroligins was increased. Neuroligins are important for the formation and regulation of connections known as synapses between neuronal cells in the brain and essential for the maintenance of the balance in the transmission of information from neuron to neuron," Prof. Sonenberg said.