(GlcNAc) and cytidine 5'-monophosphate (CMP).

A prerequisite for the synthesis of sialylatedglycoconjugates is the activated sugar-nucleotide cytidine5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), whichprovides a substrate for Golgi sialyltransferases.

Cytidine 5‘-Monophosphate (CMP)-Induced Structural …

18/12/2017 · Enzymatic synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid

Inosine triphosphate + Cytidine → IDP + Cytidine monophosphate: ..

When N9 is linked to the C1 of ribose, cytosine forms a pyrimidine nucleoside called cytidines which are phosphorylated with from one to three phosphoric acid groups to form the three nucleotides; cytidine monophosphate (CMP), cytidine diphosphate (CDP), and cytidine triphosphate (CTP) respectively. When N1 is linked to the C1 of deoxyribose, deoxy nucleosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), deoxycytidine triphosphate (dCTP).

Cytidine 5'-monophosphate, disodium salt (5'-CMP, …

The sialic acids found on eukaryotic glycans have remarkably diverse core structures, with a range of modifications at C5, C7, C8 and C9. These carbohydrates have been found to play key roles in cell−cell interactions within eukaryotes and often serve as the initial site of attachment for viruses and bacteria. Consequently simple changes to the structures of the sialic acids can result in profoundly different and often opposing biological effects. Of particular importance are modifications at the 8-position. These include -acetylation, carried out by an acetyl transferase, and particularly polysialylation, catalyzed by a polysialyltransferase. As part of a structural and mechanistic study of sialyltransferases and polysialyltransferases, access was needed to sialic acid-containing oligosaccharides that are modified at the 8-position of the sialic acid to render this center non-nucleophilic. The free 8-modified sialic acid analogues were synthesized using a concise, divergent chemical synthetic approach, and each was converted to its cytidine monophosphate (CMP) sugar donor form using a bacterial CMP-sialic acid synthetase. The transfer of each of the modified donors to lactose by each of two sialyltransferases was investigated, and kinetic parameters were determined. These yielded insights into the roles of interactions occurring at that position during enzymatic sialyl transfer. A transferase from was identified as the most suitable for the enzymatic coupling and utilized to synthesize the 8′′-modifed sialyl lactose trisaccharides in multimilligram amounts.

(2004), Enzymatic synthesis of [1-14 C-N-acetyl, P 18 O 2] cytidine monophosphate neuraminic acid
Cytidine-5'-Triphosphate Accession ..

and cytidine to uridine monophosphate and cytidine ..

Cytidine 5'-Monophosphate Disodium Salt, Hydrate, also known as 5'-cytidylic acid, is a nucleotide used as a monomer in RNA; it is also considered an ester of phosphoric acid with the nucleoside cytidine. Ungraded products supplied by TCI America are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. These materials may or may not have a Certificate of Analysis available.

Cytidine 5′-monophosphate disodium salt - Sigma …

Cytidine Monophosphate/chemical synthesis;

Cytidine 5'-Monophosphate Disodium Salt, Hydrate, also known as 5'-cytidylic acid, is a nucleotide used as a monomer in RNA; it is also considered an ester of phosphoric acid with the nucleoside cytidine. Ungraded products supplied by TCI America are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. These materials may or may not have a Certificate of Analysis available.

Sigma-Aldrich offers Sigma-C1006, Cytidine 5′-monophosphate disodium salt for your research needs

Cytidine 5-triphosphate | Define Cytidine ..

Pyrimidine bases are Cytosine, Thymine, and Uracil (examples of pyrimidine nucleosides are Cytidine, 2'-Deoxyguanosine, 5-Methyluridine, 2'-Deoxy-5-Methyluridine, Uridine, 2'-Deoxyuridine).