Bommer, U and Stahl, J (2005) Ribosomal proteins in eukaryotes. eLS.
Control of Ribosomal Protein Synthesis in Eukaryotic …
For the first time we report about the presence of genes in human RBCs encoding initiation, activation and regulation of transcription and translation (for instance RNA polymerises I,II,III, zinc/PHD finger- DNA-binding proteins, cysteinyl, lysyl-tRNA synthetase), important RNA-stabilising factor - poly(A) binding protein, anti-apoptotic proteins (for instance beclin 1, reticulon 4, BCL2, IAP) together with genes for RNA degradation (for example ribonuclease T2) as well as genes encoding typical apoptotic proteins such as cyclooxygenase, apoptotic protease activating factor, caspase 8. Other authors were able to show a protein synthesis in human platelets by megakaryocyte-derived mRNAs . The finding of RNA in anucleate cells like erythrocytes support the idea of nucleus independent protein synthesis and supports data about possible mechanism of globin m-RNA stability in human RBCs.
Control of ribosomal protein gene expression - …
Inside every cell, ribosomes read mRNA sequences and hook together protein building blocks called amino acids in the order specified by the code: Groups of three nucleotides in mRNA code for each of 20 amino acids.
Cellular site of synthesis of ribosomal proteins in yeast
Gazda HT, Sheen MR, Vlachos A et al. (2008) Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumb in Diamond‐Blackfan anemia. American Journal of Human Genetics 83: 769–780.
Genetic Control of Protein Synthesis Flashcards | Quizlet
Hagner PR, Mazan‐Mamczarz K, Dai B et al. (2011) Ribosomal protein S6 is highly expressed in non‐Hodgkin lymphoma and associates with mRNA containing a 5′ terminal oligopyrimidine tract. Oncogene 30: 1531–1541.
Mechanisms of Protein Synthesis by the Ribosome
Gazda HT, Grabowska A, Merida‐Long LB et al. (2006) Ribosomal protein S24 gene is mutated in Diamond‐Blackfan anemia. American Journal of Human Genetics 79: 1110–1118.