Wound healing and collagen formation ..

Collagen is first detected in the wound around the third day post-injury [12, 13], and thereafter the levels increase rapidly for approximately 3 weeks.

Collagen Metabolism in Wound Healing | SpringerLink

Ross R, Everett NB, Tyler R (1970) Wound healing and collagen formation.

Localization of collagen synthesis in healing wounds.

Healing in a moist environment encourages the proliferation of fibroblasts, which synthesise the elements of the new Dermal Extracellular Matrix (collagen and elastin fibre) enabling wound healing.

Localization of collagen synthesis in healing wounds ..

This was demonstrated in 1962 by Winter, who proved that healing under a synthetic semi-occlusive dressing is faster than when a wound left open to the air.

Vitamins A, B, and C for Wound Healing - Advanced Tissue

Modern medicine has made great use of silver in the form of silver nitrate sulphadiazine, in the prevention and treatment of infection in both acute and chronic wounds.

Skin Wound Healing: Overview, Hemostasis, …

Simultaneous depletion of T helper/effector and T suppressor/cytotoxic T cells leads to significant increases in both wound breaking strength and collagen synthesis [77].

Vitamin C: a wound healing perspective.

Other effects are: inhibition of procollagen production in human skin keloid fibroblast cultures
and stimulation of phagocytosis by macrophages, increased fibroblast proliferation, as well a wide variety
of cellular responses.
In vivo effects demonstrated in animals include increased formation of granulation tissue and increased
rates of epithelialisation in laser irradiated wounds, stimulation of suppressor T-cells, increased collateral
nerve sprouting and regeneration of damaged nerves in rats and tendon and ligament repair in race horses.

Vitamin C: a wound healing perspective

We found that when removed from the diabetic wound environment, HoxD3 and type I collagen expression are increased in diabetic fibroblasts when compared to wild‐type fibroblasts.

of wound healing, ECM synthesis ..

The high rate of collagen synthesis within the wound returns to normal tissue levels by 6-12 months [37], while active remodelling of the scar continues for up to 1 year after injury and indeed appears to continue at a very slow rate for life.


In particular, fibroblasts produce large quantities of collagen, a family of triple-chain glycoproteins, which form the main constituent of the extracellular wound matrix and which are ultimately responsible for imparting tensile strength to the scar.


Conversely, administration of purified thymic hormones , thymulin (FTS), thymopoietin and thymosin fraction V (TF5) results in impaired wound healing as assessed by wound breaking strength and wound collagen deposition [76].