Regulation of steroid hormone biosynthesis by the cytoskeleton.
Regulation of Aldosterone Synthesis and Secretion.
Sphingosine‐1‐phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells.
Regulation of Aldosterone Synthesis and Secretion
Involvement of protein kinase C and cyclic adenosine 3′,5′‐monophosphate‐dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells.
Cholesterol acts as the precursor for the synthesis of ..
Individuals with genetic deficiencies in the conversion of cholesterol to bile acids are treated with exogenously supplied chenodeoxycholic acid.
Figure 18.9 Synthesis of the bile acids, cholic acid and chenodeoxycholic acid, from cholesterol.
Bile salts provide the only significant mechanism for cholesterol excretion, both as a metabolic product of cholesterol and as a solubilizer of cholesterol in bile.
The synthesis of these hormones starts with cholesterol
Synthesis of bile acids
Bile acids are synthesized in the liver by a multistep, multiorganelle pathway in which hydroxyl groups are inserted at specific positions on the steroid structure; the double bond of the cholesterol B ring is reduced; and the hydrocarbon chain is shortened by three carbons, introducing a carboxyl group at the end of the chain.
REGULATION OF CHOLESTEROL SYNTHESIS • Controlled by HMG CoA ..
This results in the retention of the SCAP—SREBP complex in the ER, thereby preventing the activation of SREBP-2, and leading to downregulation of cholesterol synthesis.