Chlorobenzene for Synthesis | VWR
Effects of dietary methionine on hepatic glutathione synthesis and lipid peroxidation in rats injected with chlorobenzene were investigated. After being fed for 4 weeks on a 10% casein-based diet (basal diet) or the basal diet supplemented with 0.3% DL-methionine, rats were intraperitoneally injected with chlorobenzene at a level of 0, 0.2, 0.5, or 2.0mmol/kg body weight. In the rats fed the basal diet, a mortality of four-sixths was brought within 48 hours by the 2.0mmol/kg of chlorobenzene, and TBA value, an index of lipid peroxidation, was significantly increased by the 0.5mmol/kg of chlorobenzene. Supplementation with methionine to the basal diet made all the rats survive, and caused a lowered TBA value and a significant increase of liver wet weight in the rats in jected with the 0.5 or 2.0mmol/kg of chlorobenzene. while a significantly higher hepatic glutathione synthesis activity was observed, hepatic total glutathione level was significantly lower in the rats fed the basal diet. Chlorobenzene-induced increases in the glutathione level and its synthesis activity were observed 48 hours after the injection in the rats fed the methionine-supplemented diet but not in the rats fed the basal diet. These results indicate that chlorobenzene exposure may cause a critical impairment due to lipid peraxidation in rats fed a diet marginal in sulfur-containing amino acids.
Chlorobenzene, 99.5% for synthesis - ITW Reagents
Chlorobenzene for synthesis | VWR
Chlorinated benzenes are a group of cyclic aromatic compounds in which one or more hydrogen atoms of the benzene ring have been replaced by a chlorine atom. Chlorobenzenes are used mainly as intermediates in the synthesis of pesticides and other chemicals. 1,4-Dichlorobenzene (1,4-DCB) is used in space deodorants and as a moth repellent. The higher chlorinated benzenes (trichlorobenzenes, 1,2,3,4-tetrachlorobenzene [1,2,3,4-TeCB], and pentachlorobenzene [PeCB]) have been used as components of dielectric fluids.
Synthesis of chlorobenzene-d5 in a radiofrequency …
Chlorobenzenes are used mainly as process solvents and solvent carriers as well as parent compounds in the synthesis of pesticides (mainly), plastics, dyes, pharmaceuticals and other organic compounds.