Therefore elimination is achieved by

14. Zhang JZ, Liu XJ, Zhang JQ. . Silencing of two alternative splicing-derived mRNA variants of chitin synthase 1 gene by RNAi is lethal to the oriental migratory locust, (Meyen). 2010;40:824-833

Chitin itself is the subject of exciting medical experiments.

Chemical structures of the repeating units of idealised chitin, chitosan and cellulose.

Chitin Metabolism in Insects (PDF Download Available)

In general, chitin deposition occurs in two major extracellular structures of insects, the cuticle that overlays the epidermis, and the peritrophic membrane (PM) that lines the midgut.

Chitin Metabolism in Insects Part 1 - what-when-how

On the other hand, isolated, purified chitin is a plain polysaccharide that, at the nano level, presents itself as a highly associated structure, recently refined in terms of regularity, nature of bonds, crystallinity degree and unusual colloidal behavior.

Khoushab F and Yamabhai M (2010) Chitin research revisited. Marine Drugs 8: 1988–2012.

Chitin is found in insects and fungus and ..

19. Ampasala DR, Zheng SC, Zhang DY. . An epidermis-specific chitin synthase cDNA in : cloning, characterization, developmental and hormonal-regulated expression. 2011;76:83-96

The chitin synthesis inhibitor will begin ..

18. Mayer RT, Chen AC, DeLoach JR. Chitin synthesis inhibiting insect growth regulators do not inhibit chitin synthesis. 1981;37:337-338

Biologically inspired synthesis has been used for the production of mineral-chitin composites.

Chitin is tough, biodegradeable and relatively inert

Bo M, Bavestrello G, Kurek D et al. (2012) Isolation and identification of chitin in the black coral Parantipathes larix (Anthozoa: Cnidaria). International Journal of Biological Macromolecules 51: 129–137.

The prototypic chitinase, acidic mammalian chitinase, was also noted to be induced during T(H)2 inflammation through an IL-13-dependent mechanism.

Chitin Synthesis Inhibitors, ..

Hartl L, Zach S and Seidl‐Seiboth V (2012) Fungal chitinases: diversity, mechanistic properties and biotechnological potential. Applied Microbiology and Biotechnology 93: 533–543.

40. Zimoch L, Hogenkamp DG, Kramer KJ. . Regulation of chitin synthesis in the larval midgut of .  2005;35:515-527

Chitin synthesis has been used as a target for developing ..

The Diptera evolved along two major lines: an assemblage of suborders corresponding to the mosquitoes, including the basal Diptera, and the suborder Brachycera, which includes the most evolved flies (Cyclorrhapha). The Diptera ancestor is similar to the hymenopteran-panorpoid ancestor (Fig. 5C) in having the enzymes involved in intermediate digestion free in the ectoperitrophic fluid (mainly in the large ceca), whereas the enzymes of terminal digestion are membrane bound at the midgut cell microvilli. Although these characteristics are observed in most nonbrachyceran larvae, the more evolved of these larvae may show reduction in size of midgut ceca (e.g., Culicidae, Fig. 2K). Nonhematophagous adults store (nectar or decay products) in their crops and carried out digestion and absorption at the anterior midgut. Blood, which is sucked only by females, passes to the posterior midgut, where it is digested and absorbed.
The Cyclorrhapha ancestor (Fig. 5D) evolved dramatically from the hymenopteran-panorpoid ancestor (Fig. 5C), apparently as a result of adaptations to a diet consisting mainly of bacteria. Digestive events in Cyclorrhapha larvae are exemplified by larvae of the house fly Musca domestica. These larvae ingest food rich in bacteria. In the anterior midgut, there is a decrease in the starch content of the food bolus, facilitating bacteria death. The bolus now passes into the middle midgut where bacteria are killed by the combined action of low pH, a special lysozyme, and an aspartic proteinase. Finally, the material released by bacteria is digested in the posterior midgut. Countercurrent fluxes occur in the posterior midgut powered by secretion of fluid in the distal part of the posterior midgut and its absorption back into the middle midgut. The middle midgut has specialized cells for buffering the luminal contents in the acidic zone (Fig. 3D), in addition to those functioning in fluid absorption (Fig. 3A). Except for a few bloodsuckers, cyclorrhaphan adults feed mainly on liquids associated with decaying material (rich in bacteria) in a way similar to house fly adults. The stable fly, Stomoxys calci-trans, stores and concentrates the blood meal in the anterior midgut and gradually passes it to the posterior midgut, where digestion takes place, resembling what occurs in larvae. These adults lack the characteristic cyclorrhaphan middle midgut and the associated low luminal pH. Stable flies occasionally take nectar.