A variation of this pathway is the decreasing potential hypothesis
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This is of course highly speculative, but the resulting molecule is for example an almost exact substructure of , which inhibits a Ribosomal protein S6 kinase (p90RSK). RSKs have been reported to be important in preventing apoptosis.
This hypothesis prompted us to compare the pool of ..
I don’t think we can already start pointing fingers at the reactive nature of the molecule. Many people here point out the problem of neoantigen formation. But that (to my knowledge) is loinked to a risk of idiosyncratic tox. Having most (all) of one cohort developing such side effects in a matter of days does not look like idiosyncratic tox at all, like others have already pointed out.
More likely to be an off target effec tthat was not adequately visible in preclinical species (with or without intervention of the reactive moiety). And this kind of thing can happen even without anybody screwing up: imagine an off-target for which the molecule has no cross-reactivity vs the preclinical species, and which is not a part of the standard selectivity panels. In a number of human targets I worked on it was hard to get compounds cross-reacting vs the human target (e.g. chemokine receptors). If that happens with a toxicophoric target you are screwed…
Roger W. Sperry : Wikis (The Full Wiki)
Historical examples of work-related cancer clusters are well documented in the medical literature.
is a peer-reviewed medical journal devoted to research in the field of cancer epidemiology.
the entire wiki with video and photo galleries ..
In the linear differentiation pathway, memory T cells develop from already existing effector T cells. The effector T cells differentiate into memory T cells after the antigen has disappeared. The memory T cell can then later differentiate back into an effector cell if it encounter antigens of the reoccurring pathogen. A variation of this pathway is the decreasing potential hypothesis. This hypothesis follows the same idea that memory cells arise from effector cells. However, in this model the early effector cells can differentiate into one type of a memory cell when no antigen is present(TCM) and the late effector cells can differentiate into another type of a memory cell when no antigen is present (TEM). These memory cells can later differentiate into the memory cells that result from the early effector T cells (TCM). Both of these pathways are shown in the figure to the right, letters b and c.