TN-101 – Oil of Catnip by Supercritical Fluid Extraction
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Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc.,
The reaction product is analyzed to determine how changes in these parameters change yield, purity, and economics of the proposed process. This information can then be utilized to fine tune the reaction to maximize key parameters for a commercial scale reaction process or simply be used for repetitive laboratory scale applications. Examples demonstrating the utility of a High Pressure Reaction Unit for traditional organic synthesis and supercritical fluid synthesis are presented.
Kenneth J. James, Ph.D.,* Supercritical Fluid Technologies, Inc.
Supercritical Fluid Technologies has announced the introduction of a new version of their SFT-NPX-10 pilot-scale natural products CO2 extractor optimized for the production of pharmaceutical-grade cannabis oil. The new NPX-10 is designed to simplify extraction by utilizing safe, efficient carbon dioxide. It may be used to facilitate the transition from laboratory scale equipment to large production scale systems.
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J.A.R. Uribe et al. / J. of Supercritical Fluids 56 (2011) 174–178
This review presents comprehensive tables of the systems which have been studied in supercritical fluids, along with a brief description of the recent trends in the area.
reported as supercritical fluids for biodiesel synthesis ..
Coprecipitation of active pharmaceutical ingredients (API) with additives can provide the ability to add functionality to API’s at early stages of drug discovery and synthesis. It is with this objective that a number of drugs were recrystallized in the presence of structurally related additives. The rapid expansion of supercritical solution (RESS) process was evaluated to recrystallize the drug–additive mixtures. Results of RESS aided coprecipitation studies involving twelve drug–additive mixtures are reported in this manuscript. Characterization of these mixtures revealed a number of interesting phenomena. These include habit modification, solubility enhancement, particle size reduction, eutectic formation, reduction in crystallinity, amorphous conversion, hydrate formation, polymorph conversion and selective extraction. In viewing each of these phenomena from an application standpoint, this manuscript serves as proof of concept for altering the physicochemical and mechanical properties of API’s using supercritical fluid (SCF) coprecipitation. It was concluded from these studies that the rapid crystallization conditions offered by the SCF media alone does not provide the ability to consistently dope crystals. Competing mechanisms based on the relative solubility of drugs and additives in SCF media, as well as the selectivity of SCF solvents are to be taken into consideration while undertaking coprecipitations.