Process for triphosphate oligonucleotide synthesis.
A universal glass support for oligonucleotide synthesis.
So far, the reactions you have seen have only one product molecule on the right-hand side of the chemical equation. Be on the lookout for synthesis reactions with multiple products. A familiar example of a more complex synthesis reaction is the overall equation for photosynthesis:
RNA oligonucleotide synthesis via 5′‐silyl‐2′‐orthoester chemistry.
AB - Studies of the interaction between the small molecules and DNA, especially the effects of the structural characteristics of the small molecules on the DNA interaction, are very important for the design of DNA targeting new drugs. In this context, the development of photochemical DNA cleaving agents, which selectively cleave DNA by irradiation with light of a specific wavelength under mild conditions and without any additives such as metals and reducing agents, is very interesting from chemical and biological standpoints and offers considerable potential in medicine especially in the post-genome era. In this article, the molecular design, chemical synthesis, DNA photocleaving property and photo-selective cytotoxicity of such novel and artificial light activatable DNA cleaving agents, which consist of DNA intercalator and carbohydrate, are described.
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Another major bottleneck for DNA origami has been that scientists typically produce staples via expensive and time-consuming chemical synthesis, so these DNA architects tend to work with mere micrograms of material. Yet biomedical applications, such as drug encapsulation and delivery, may require many grams for testing in animals. “There’s no way you can pull that off unless you can make a lot of these things,” Dietz says.
Recombinant DNA technology in the synthesis of …
They are building blocks for the synthesis of pharmaceutical oligonucleotide analogues and initial compounds for preparation of corresponding nucleoside 5'-di- and triphosphates.
Oligonucleotide Synthesis | Custom DNA & RNA …
Metkinen Chemistry offers a full set of 2-F-nucleoside CE-phosphoramidites for the chemical synthesis and a full set of 2-F-nucleoside 5-triphosphates for enzymatic preparation of FANA.