Sanofi’s API produced from semisynthetic artemisinin (artesunate) ..
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Because the chemical synthesis of ..
Dr Denis Barron is the head of the Natural Bioactives & Screening department at Nestlé Institute of Health Sciences (NIHS), Lausanne, Switzerland. He first studied Pharmacy at the Universities of Clermont-Ferrand and Grenoble. He obtained his PhD in 1987 from Concordia University (Montreal, Canada), where he worked on the phytochemical characterization, the chemical synthesis and the enzymatic synthesis of plant sulfated flavonoid. Then he entered the French institute of Agriculture (INRA) in Dijon as a research assistant in the field of aroma research. In 1989, he got an assistant professorship in Pharmacognosy at the school of Pharmacy of Grenoble (France), and developed a number of synthetic tools for the organic synthesis of isoprenoid flavonoids. In 1994, he was nominated full professor in plant biochemistry at University of Lyon (France). His research interest was oriented towards the discovery of natural inhibitors of cellular efflux pumps that are involved in chemoresistance and nutrient absorption such as P-glycoprotein and MRP. Dr Barron research activities, at the boarder of pharmacy and nutrition, gave him the opportunity to join Nestlé Research Center (NRC) in Lausanne in 2003. At NRC his research activities were oriented towards the human metabolism of dietary polyphenols, and towards the characterization of bioactive compounds from food ingredients. In 2012, he moved to NIHS. His current activities aim at identifying natural food products and extracts that are relevant in the prevention and the treatment of metabolic, brain, and gastro intestinal diseases.
Artesunate (AS) is a medication used to treat malaria
Professor Dr. Prof. h. c. mult. Thomas Efferth is chair of the Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany. He is biologist by training (Technical University of Darmstadt, Germany). His doctoral thesis was completed at the German Cancer Research Center (DKFZ), Heidelberg, Germany (1990). Dr. Efferth was awarded the Ludolf-Krehl-Prize of the Southwest German Association for Medicine (1991), the Willmar-Schwabe-Award of the German Society for Medicinal Plant Research (2006), the citizen medal of the City of Heidelberg, Germany (2008), the CESAR Award for Translational Oncology (2011), and the SCENTEDdrop Award on medicinal and flagrant herbs (2015). He headed a research group for Pharmaceutical Biology at DKFZ (2005-2009) and was associate professor (apl) at the University of Heidelberg (2007-2009). In 2009, he took over the Chair of Pharmaceutical Biology (full professorship) at the Johannes Gutenberg University, Mainz. Furthermore, he is honorary professor at the Northeast Forestry University, Harbin, and at the Zhejiang Chinese Medical University, Hangzhou, China. Moreover, he is visiting professor at the Zhejiang University of Science and Technology, Hangzhou, China.
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