Clean Chemical Synthesis in Water - Organic chemistry

The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural products that have likely been known to man since antiquity. In more recent times, these alkaloids have been discovered to span a wide range of chemical structures that possess a number of interesting biological activities. This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, research toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively reviewed. Finally, the current, evidence-based understanding of the various biosynthetic pathways employed by bacteria to produce prodiginine alkaloids is summarized.

The Chemical Synthesis Of Natural Products - …

Natural product total synthesis provides a core component of many of the organic research programs

Book Series: Studies in Natural Products Chemistry

Natural products remain the best sources of drugs and drug leads, naturalproducts research in favor of HTP screening of combinatorial libraries duringthe past 2 decades. possessstructural and chemical diversity that is unsurpassed by any syntheticlibraries.

Series: Studies in Natural Products Chemistry

An advance in technology and sensitive instrumentation for therapid identification of novel bioactive natural products and structureelucidation continues to improve the natural product discovery process. hasindeed revolutionized the development of novel active chemical leads resultingin the synthesis of structural analogues. constitutea key source of pharmacologically active ingredients in a variety of novelagents with therapeutic potential in a wide range of diseases. containingnatural products or compounds derived from natural product scaffolds ortemplates have to undergo the same stringent approval process as drugs obtainedfrom purely synthetic origin.

Nature has provided a fascinating array of chemicalstructures in the form of bioactive secondary metabolites.

Synthesis of natural product inspired compound collections.

N2 - Microbially derived modular polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways are a rich source of novel natural products. Development of these systems for the engineered biosynthesis of diverse secondary metabolites continues to progress as a robust source of chemical diversity. Recent efforts that employ individual enzymes and catalytic domains for the production or modification of small molecules have met with growing success. In this study, the thioesterase domain from the cryptophycin biosynthetic pathway was isolated and its function evaluated with a series of linear chain elongation intermediates in developing a novel chemoenzymatic synthesis of the cryptophycin/ arenastatin class of antitumor agents. The results show the high efficiency of the thioesterase in generating the 16-membered depsipeptide ring of this important natural product system. Moreover, analysis of selected substrates revealed considerable tolerance for structural variation within the seco-cryptophycin unit C β-alanine residue, but strict structural requirements at the phenyl group position of the unit A δ-hydroxy octadienoate chain elongation intermediates.

Chemical Synthesis of Novel Natural Products - David …

Using ESIPT photocycloaddition, approaches will be outlined to synthesize the natural product methyl rocaglate and derivatives as well as the promising anticancer agent silvestrol, a natural product derived from a plant found in Malaysia which is being developed as a treatment for acute lymphoblastic leukemia.

Synthesis of Natural Products - Department of Chemistry

AB - The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural products that have likely been known to man since antiquity. In more recent times, these alkaloids have been discovered to span a wide range of chemical structures that possess a number of interesting biological activities. This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, research toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively reviewed. Finally, the current, evidence-based understanding of the various biosynthetic pathways employed by bacteria to produce prodiginine alkaloids is summarized.