Protein synthesis - Biology-Online Dictionary
Video: Protein synthesis: an epic on the cellular level
Under non-dieting circumstances, although AMPk will be activated during training, impairing protein synthesis, providing nutrients afterwards (i.e. carbs + proteins) is known to reverse the catabolic processes and turn on anabolic processes. Making me wonder if pre- or during-workout nutrition can actually prevent the activation of AMPk in the first place (by limiting the drop in cellular energy charge). To my knowledge, it hasn’t been studied but it would make some logical sense.
Protein synthesis: an epic on the cellular level
AMPk and its function also explains one of the older models of hypertrophy whereby protein synthesis was acutely depressed during exercise. Activation of AMPk during exercise directly inhibits mTOR and protein synthesis. The recovery of cellular energy post-workout allows protein synthesis to increase and growth to occur. Note also the huge push on the provision of amino acids, specifically leucine, post-workout as leucine directly activates mTOR, turning on protein synthesis.