P-450 is cytochrome P-450 enzymes.

There is evidence to suggest that liver cytochrome P-450 is similar to that of the kidney, based on electro-phoretic and electron paramagnetic resonance studies (Armbrecht et al., 1979), immunological criteria (Guengerich & Mason, 1979), and on immunometabolic studies (Kaminsky et al., 1979).

Renal cytochrome P-450 induction varies in different species.

Multiple forms of cytochrome P-450 have been identified in the kidney.

The active site of cytochrome P450 contains a heme-iron center

In the male rat kidney, studies with perdeutero-DBCP indicate that DBCP is not metabolized by cytochrome P-450, but presumably by glutathione S-transferase.

Cytochrome P450 - an overview | ScienceDirect Topics

1,2-Dibromoethane and DBCP are metabolized in the liver by both cytochrome P-450 oxidative dehalogenation and by glutathione- S-transferase-mediated substitution.

Cytochrome P-450 is not detected in the medulla of controls or even those of induced animals.

Enzymes of the cytochrome P450 (CYP) ..

This variability of cytochrome P450 enzymes is seen in the variability of people's ability to detoxify the carcinogens found in cigarette smoke and helps to explain why some people can smoke with only modest damage to their lungs, while others develop lung cancer after only a few decades of smoking.

CYTOCHROME P-450 3A4: Regulation and Role in ..

A considerable amount of research has found that various substances activate cytochrome P450 while others inhibit it.

Good picture of Phase I activities: Good picture of Phase I enzymes:

Cytochrome P450 1A2 (CYP1A2) ..

Cytochrome P-450 mixed-function oxidase activities have been shown immuno-histochemically to be localized in the proximal tubule, particularly in the S2 and S3 segments in the Table 4.

Cytochrome P450 enzymes in drug metabolism: Regulation …

The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

(1979) Renal cytochrome P-450's - Electrophoretic and electron paramagnetic resonance studies.

Cytochrome P450: the importance of ..

Hexachloro-1,3-butadiene (HCBD) is metabolized in the liver probably by GSH S-transferasecatalysed halogen substitution rather than a cytochrome P-450-mediated reaction to the GSH conjugate.

(1979) NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

Cytochrome P-450 reductase - Revolvy

The mutagenicity of DACs (50 nmol/plate) in Ames tests using human liver microsome preparations from 10 individuals was compared with cytochrome P450 (CYP) activity in each microsome preparation to investigate the CYP isoform involved in the activation of DACs to the genotoxic forms.

(1980) The distribution and role of cytochrome P-450 in extrahepatic organs.

Effect of Cyclosporine A on Cytochrome P-450-Mediated …

"Determination of caffeine and metamizole elimination in pregnancy and after delivery as an in vivo method for characterization of various cytochrome p-450 dependent biotransformation reactions".