Complex-Shaped Metal Nanoparticles: Bottom-Up ..
Nanoparticle Synthesis: Top-Down via: Bottom-Up via: ..
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Bottom-up synthesis of Zn1.7GeN1.8O nanoparticles …
65. Zhang G, Liao Y, Baker I. Surface engineering of core/shell iron/iron oxide nanoparticles from microemulsions for hyperthermia. 2010;30:92
Nanowire Synthesis: From Top-Down to Bottom ..
36. Yigit MV, Mazumdar D, Lu Y. MRI detection of thrombin with aptamer functionalized superparamagnetic iron oxide nanoparticles. 2008;19:412-7
Drawing upon the solution-phase synthesis of nanoparticles, ..
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Copper Nanoparticles: Synthetic Strategies, Properties …
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Copper nanoparticles; synthesis; top-down; bottom-up…
Richards-Kortum reported a novel approach to conjugating nanoparticles and aptamers . The aptamer was extended to provide a hybridization site for complementary ONT-coated nanoparticles. GNPs (20 nm) were coated with thiol-modified capture ONTs containing a hexa(ethylene glycol) spacer and a complementary sequence for the aptamer extension, and the extended anti-PSMA aptamer was hybridized to capture ONT-coated GNPs by heating the solution at 70°C for 5 min, followed by incubation at room temperature for 30 min. The resulting aptamer-GNPs showed targeted detection of LNCaP (PSMA+) cells via reflectance imaging. This conjugation strategy has several advantages. First, the negatively charged phosphate groups of the ONTs prevented aggregation of the nanoparticles through electrostatic repulsion, leading to nanoparticle stability, even in high-salt environments. Second, aptamers were easily conjugated to the surfaces of nanoparticles via complementary sequence hybridization with the capture ONTs, which preserved the aptamer integrity and stability during bioconjugation. A PEG spacer between the thiol group and the complementary capture sequence of capture ONT improved the hybridization efficiency by minimizing steric hindrance between the gold surface and the hybridization site. Third, a small number of aptamers was needed for binding to the nanoparticles through the short cheap capture ONTs, unlike thiolated aptamers, in which significant concentrations of aptamers are necessary to coat and stabilize the nanoparticles. Finally, multiplexing capabilities can be obtained by incorporating other types of molecules (targeting, delivery, imaging, or therapeutic agents) into the nanoparticles.