2. Biosynthesis of Plasmalogens and Alkylacylglycerophospholipids
Different Types of Sphingolipids and Their Biosynthesis
In T. brucei, PS represents a minor membrane component [,]. Its biosynthetic pathway has not been firmly established [,]. A candidate gene encoding a putative PS synthase, or a PSS2, has been identified in the T. brucei genome (, ). Experiments to establish the route for PS formation in T. brucei are currently under way in our laboratories.
Reactions involved in the biosynthesis of glycerophospholipids
Araki W and Wurtman RJ (1998) How is membrane phospholipid biosynthesis controlled in neural tissues? Journal of Neuroscience Research 51: 667–674.
The base exchange pathway for phosphatidylserine synthesis ..
Completion of the Tri-Tryp (T. brucei, T. cruzi, Leishmania spp.) genome projects () has allowed putative identification of homologues of genes necessary for de novo biosynthesis of all classes of phospholipids. Recently, several biosynthetic enzymes involved in de novo synthesis of phospholipids have been characterized experimentally, including enzymes involved in de novo synthesis of fatty acids and the major glycerophospholipid and sphingolipid classes, and several catabolic enzymes, including two phospholipases and a sphingomyelinase (see below). As more enzymes involved in phospholipid metabolism are characterized, our understanding of these parasites will allow direct comparisons with man, and thus new targets are likely to emerge for the development of new anti-protozoan drugs.