BIOSYNTHESIS AND CATABOLISM OF PYRIMIDINENUCLEOTIDES.
There are 4 purines and 4pyrimidines that are of concern to us.
The biosynthesis of purine and pyrimidine nucleotides takes place over synthetic pathways from small molecules and by salvage pathways from preformed purine or pyrimidine bases or nucleosides. The pathways of synthesis are the same in animals and microorganisms. Salvage pathways are considerably more energy‐efficient than pathways, which require 5 (pyrimidine) or 6 (purine) moles of ATP for each mole of nucleotide produced. Salvage pathways are integral to the cause or treatment of a number of human diseases of purine or pyrimidine metabolism. Among disorders of purine metabolism, the Lesch–Nyhan disease is characterised by overproduction of uric acid, clinical gout, nephropathy, neurologic disease, and unusual self‐injurious behaviours.
Purine and Pyrimidine Nucleotide Biosynthesis - YouTube
pathways; enzymes; human disorders; purines; pyrimidines; adenine phosphoribosyltransferase (APRT); hypoxanthine guanine phosphoribosyltransferase (HGPRT)
Inhibition of Pyrimidine Biosynthesis Pathway ..
Carbamoyl phosphate utilizedin pyrimidine nucleotide synthesis differs from that synthesized in the ureacycle; it is synthesized from glutamine instead of ammonia and is synthesizedin the cytosol.
de novo purine biosynthetic pathwayRat Genome …
We examine here the biosyntheticpathways of purine and pyrimidine nucleotides and their regulation, theformation of the deoxynucleotides, and the degradation of purines andpyrimidines to uric acid and urea.
de novo purine biosynthetic pathwayRat Genome Database ..
For purines, especially, non-hepatic tissues relyheavily on preformed bases - those salvaged from their own intracellularturnover supplemented by bases synthesized in the liver and delivered totissues via the blood.