Biosynthesis of the Peptidoglycan of Bacterial Cell Walls
Peptidoglycan structure and biosynthesis - YouTube
Compound 2, in itsvarious peptideforms, is believed to be an important player both in peptidoglycanrecycling events and in an induction event that leads to the expressionof β-lactamase, a key β-lactam antibiotic resistanceenzyme
We are interested in the structural characterization of cell wallremodeling and its implications in antibiotics resistance and virulence.
Peptidoglycan layer is also the structure of bacterial cell wall
Great variation occurs in the composition of the sugars in the Osidechain between species and even strains of Gram-negative bacteria. Atleast20 different sugars are known to occur and many of these sugars arecharacteristicallyunique dideoxyhexoses, which occur in nature only in Gram-negative cellwalls. Variations in sugar content of the O polysaccharide contributetothe wide variety of antigenic types of and and presumably other strains of Gram-negative species. Particularsugarsin the structure, especially the terminal ones, confer immunologicalspecificityof the O antigen, in addition to "smoothness" (colony morphology) ofthestrain. Loss of the O specific region by mutation results in the strainbecoming a "rough" (colony morphology) or R strain.