T1 - Biosynthesis of membrane lipids
T1 - Impaired membrane traffic in defective ether lipid biosynthesis
Gliozzi A, Relini A and Chong PL‐G (2002) Structure and permeability properties of biomimetic membranes of bolaform archaeal tetraether lipids. Journal of Membrane Science 206: 131–147.
He proposed that the cellmembranes were made of lipids.
Tenchov B, Vescio EM, Sprott GD et al. (2006) Salt tolerance of archaeal extremely halophilic lipid membranes. Journal of Biological Chemistry 281: 10016–10023.
Lipids of the Plant Plasma Membrane
AB - Non-acetylated glucosamine is an unusual structural feature shared by all glycosyl phosphatidylinositol (GPI) lipids, including a variety of membrane anchors, the leishmanial lipophosphoglycan, and a mediator of insulin action. We proposed previously a pathway for biosynthesis of glycolipid A, the precursor of the GPI membrane anchor of the trypanosome variant surface glycoprotein (Masterson, W.J., Doering, T.L., Hart, G.W., and Englund, P.T. (1989) Cell 56, 793-800). In this paper we characterize in more detail the initial steps of GPI assembly. The first and committed step in the pathway is the transfer of GlcNAc, from UDP-GlcNAc, to endogenous phosphatidylinositol to form N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI). The GlcNAc-PI is then efficiently deacetylated to form glucosaminyl phosphatidylinositol (GlcN-PI), the substrate for subsequent reactions en route to glycolipid A.