A 1,5-benzothiazepine synthesis

Optically active 1, 5- benzothiazepines belong to the well known benzothiazepine type substances. Some of them possess important bioactivities. In this article, optically active 2, 3-dihydro-1, 5-benzothiazepine derivatives are synthesized by the reaction of new α-β unsaturated carbonyl compounds with 2-aminothiophenol under mild conditions in the presence of silver sulphate in acetonitrile in short reaction time with excellent yield. The structures of newly synthesized compounds were confirmed by spectral evidence and the compounds were evaluated for their anti-bacterial and antifungal activity. All synthesized compounds have shown excellent results.

Benzothiazepine essay synthesis

Synthesis and Steric Structure of α-Amino-β-lactam Derivatives of 1,5-Benzothiazepines[J].
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Pharmacological and synthetic profile of benzothiazepine: ..

CONCLUSIONS: The results of the present investigation can be summarized that we have develop a new, mild and efficient method for the synthesis of 1, 5-benzothiazepines,workout is easy, reaction conditions are mild and yield is excellent 75-85% , structures of the synthesized compounds were confirmed by spectral analysis. It supports the suggested anti- bacterial pharmacophoresites of 1, 5- benzothiazepine derivative. It has been suggested that some functional groups such as halogen group particularly fluorine and side chain present in these compounds displayed roles of biological activity, this, in turn, enhances activity of the compounds and biological absorbance, and so all the synthesized 1, 5-benzothiazepine derivatives containing more than one antibacterial and antifungal pharmacophore site have excellent properties.

Pharmacological and synthetic profile of benzothiazepine: A ..

General procedure for the synthesis of 1, 5-benzothiazepines: A mixture of 2-aminothiophenol 1 (10 mmole), α -β unsaturated carbonyl compounds 2 (10 mmole) and Silver sulphate (catalytic amount) were refluxed in 10ml of acetonitrile for 2hr, completion of the reaction was monitored on TLC. The solvent evaporated under reduced pressure, solid separated recrystallized from suitable solvents which was further purified by column chromatography, to afford novel 1, 5- benzothiazepine derivatives in excellent yield (75-85%) (Scheme 1).

This study was designed to synthesized; identify and antidepressant-like activity of novel derivatives of benzothiazepine.
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Rhodium-Catalyzed [4 + 3] Annulations of Sulfoximines …

Antidepressants are the drugs used to treat depression thereby elevates mood and modifies the behavior. The main aims in the development of new antidepressants were greater efficacy, absence of side effects, lack of toxicity in over dose and earlier onset of action. In this study, a series of novel substituted benzothiazepine was synthesized and evaluated for antidepressant-like activity by using or forced swim test (FST).

A practical synthesis of 2,3-dihydro-1,5 …

The retrievable nanostructure catalyst was asserted to be an efficient catalyst in the synthesis of benzothiazepine and spirobenzothiazine chroman derivatives through three-component reaction of coumarine-3-carboxylic acid derivatives, 2-aminothiophenol, and alkyl isocyanides at room temperature under mild conditions.

Benzothiazepine synthesis essay

An efficient and rapid synthesis of some new pyrazoles, isoxazole, benzoxazepine and benzothiazepine derivatives is described. The synthesized compounds were investigated for their anti-inflammatory and antimicrobial activities and some of them showed potent anti-inflammatory and anti-microbial activities.

09/01/2011 · A 1,5-benzothiazepin..

Sanjeevan Gaikwad, Synthesis and antimicrobial study of novel 2, 3-diydro -4-(naphtho [2, 1-b] furan -2yl)-2-substitued [1, 5]benzothiazepines, Journal of Chemical, Biological and Physical Sciences,(2013) 2249 1929.

Study of the reaction of chalcone analogs of …

Our synthetic route started from substituted aromatic aldehyde which was reacted with 2-aminothiophenol and ethyl or methyl acetoacetate led to the formation of the title compounds. Total 22 benzothiazepine derivatives were synthesized. All compounds were tested for antidepressant activity by using or forced swim test (FST).