Natural sources of benzoic acid

As with benzoic acid in recombination assays with Bacillus subtilis H17 and M45, positive results were obtained (Ishizaki & Ueno, 1989; Nonaka, 1989).

Determination of sorbic acid, benzoic acid, and saccharin in yogurt.

In practical food preservation, the Na salt of benzoic acid is the most widely used form (see ).
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For sodium benzoate, negative results were obtained in vivo in a cytogenetic assay with rats and a host-mediated assay with single or multiple oral application.

; C7H5O2Na; benzoic acid, sodium salt [E 211 (EU No.

Studies on the precursors of benzoic acid support the notion that benzoic acid is unlikely to have adverse reproductive effects at dose levels not toxic to the mother.

WHO Library Cataloguing-in-Publication Data Benzoic acid and sodium benzoate.
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Maki T, Suzuki Y (1985) Benzoic acid and derivatives.

In different experiments with rabbits, which have not been performed according to current guidelines, benzoic acid applied as dry powder or in the form of a paste was not irritating to slightly irritating to the skin (score 1.66/8: Bio-Fax, 1973; no score given: Bayer AG, 1978; primary skin irritation index 0.5 [no further information available]: RCC Notox, 1988a).

(1983) Primary eye irritation of benzoic acid to rabbits.

In a maximization test, none of 15 guinea-pigs reacted positively after induction and challenge with a 10-20% solution of benzoic acid in water (Gad et al., 1986).

Srour R (1998) Benzoic acid and derivatives.

8.2.1 Benzoic acid Although there is a wide range of results from mostly non-standardized tests using various scoring systems, it can be concluded that benzoic acid is slightly irritating to the skin and irritating to the eyes.

Benzoic acid was not skin sensitizing in several animal models.

For comparison, a similar calculation with sugar-free marmalade, jam, and similar spreads, which are allowed to contain higher levels of benzoic acid (500 mg/kg; EC, 1995), would result in a possible intake of 4.1 mg per person per day, or 0.06 mg/kg body weight per day (assumes a daily consumption of 8.2 g, according to BAGS, 1995).

Benzoic acid occurs naturally in many plants.

After oral and dermal uptake, benzoate is metabolized in the liver by conjugation with glycine, resulting in the formation of hippuric acid (Feldmann & Maibach, 1970; US FDA, 1972a; WHO, 1996; Feillet & Leonard, 1998).

In: Physiological activity of benzoic acid and sodium benzoate.

In an acute eye irritation/corrosion study with rabbits conducted according to OECD Guideline 405, some eye irritation was reported after application of benzoic acid in the form of a paste.