3 benzazepine synthesis essay - Records From Shelf
A synthesis of 6, 7-dimethoxy-3-phenyl-1, 2, 3, 4-tetrahydroisoquinoline (14a) and 7, 8-dimethoxy-2-phenyl-1, 2, 4, 5-tetrahydro-3H-3-benzazepine (14b) was achieved via the cyclization of N-(3, 4-dimethoxyphenyl)methyl-1-phenyl-2-(phenylsulfinyl)ethylformamide (6a) and N-2-(3, 4-dimethoxyphenyl)ethyl-1-phenyl-2-(phenylsulfinyl)-ethylformamide (6b) using the Pummerer reaction as a key step, respectively. The Pummerer reaction of 6a, b under usual conditions using trifluoroacetic anhydride yielded the vinyl sulfides (8a, b), non-cyclized products, as a major product. The cyclization proceeded when boron trifluoride diethyl etherate was used as an additive reagent, thus giving rise to the corresponding cyclized products (7a) and (7b) in moderate yields. We propose that the enhancing effect of the Lewis acid on the cyclization may be attributable to the involvement of a dicationic intermediate, sulfonium-carbenium dication (23).
Novel synthesis of the 2-benzazepine system, …
Synthesis of Benzazepine Analogues of Noscapine
Part 86 : Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 9-chloro-5,6-dihydropyrimido[5,4-d]benzazepine and related compounds. / Okuda, Kensuke; Takarada, Shigeki; Hirota, Takashi. In: , Vol.
Methods Of Synthesis Of Benzazepine Derivatives
Part 86: Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 9-chloro-5,6-dihydropyrimido[5,4-d]benzazepine and related compounds.
Dopamine receptor D1 - Wikipedia
The principle peptide constraint structure, 2-(7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin-2-yl)-ethanoic acid (8) and some structurally related benzazepine analogues were synthesized and incorporated into peptides using solid-phase protocols.