Biosynthesis of bacitracin on a protein thiotemplate.

Bacitracin is one of the most important polypeptide antibiotics; it is produced by some strains of and and functions as an inhibitor of the cell wall biosynthesis. It is a potent antibiotic used clinically in combination with other antimicrobial drugs (Cao and Helmann, 2002). Bacitracin inhibits preferentially the growth of and (Bass ., 1997; Skaar ., 1994). Bacitracin is composed of 12 residues and it is produced non-ribosomally by the thiotemplate mechanism (Eppelmann ., 2001).

Biosynthesis of bacitracin - ResearchGate

Enzyme-Bound Intermediates in the Biosynthesis of Bacitracin

Fermentation media used for the production of bacitracin by cells were either natural, like soya bean extract and beef extract, or minimal media containing different carbon and nitrogen sources like amino acids, carbohydrates (glucose and sucrose) and some s (Rabinovitch and Filho, 1982; Hanlon and Hodges, 1981). Biosynthesis of bacitracin in solid-state fermentation by using defatted oil seed cakes of agricultural by-products was recently reported (Farzana ., 2005).

Enhancement of bacitracin biosynthesis by branched …

It inhibits, like vancomycin, the biosynthesis of the cell wall, preferentially gram positive bacteria and cocci, by binding to bactoprenyl pyrophosphate.
: Bacitracin is employed as a protease inhibitor, too.

Antibiotics are molecules that ..

The mechanism of action of many common antibiotics is to interfere with some reactions of peptidoglycan biosynthesis. Listed below are examples:
Bacitracin: interferes bactoprenol returning to the cytoplasmic side of the membrane.
Vancomycin: Prevents cross-link of glycan chains.

05/01/2010 · Brazilian Journal of Microbiology ..

The possibility of an amino acid control mechanism for bacitracin ..