preparation of acetylsalicylic acid or aspirin
Synthesis and Characterization of Aspirin - Odinity
It was reported for the first time in the seed oil of the desert rose Adenium obesum in which it is present at a level of around 26 % (Smith MA et al., JAOCS 2016, 93, 105).
This fatty acid was named strophantus acid and it is a potential renewable feedstock for the oleochemical industry, mainly as a precursor for the synthesis of antimicrobial compounds.
As castor seed production presents some problems (toxicity of the seed, allergic reactions), species were proposed as a valuable source in the USA (up to 70% in the oil) of ricinoleic acid but also of lesquerolic acid, the C20 homologue of ricinoleic acid (14-hydroxy-11-eicosenoic acid).
Synthesis of Aspirin- A Lewis Acid Approach | VIPEr
Old COX inhibitors – NSAIDs such as aspirin and ibuprofen – inhibit the actions of both COX1 and COX2. Suppressing the bad COX2 accounts for the drugs’ therapeutic effects. Suppressing the good COX1 leads to their undesirable side effects. Different drugs have different selectivity for the two COXs, which partly explains their varying medicinal profiles. Unfortunately, they all tend to be harsher on the good COX1. The worse is aspirin itself. It is 150 times more effective in inhibiting COX1 than COX2, and is harsher on the stomach than its cousins.