New syntheses of 5,6- and 7,8-diaminoquinolines
Synthesis of Quinolines, Chemistry tutorial - TutorsGlobe
The never discussed problem with this reaction is that it requires excess reacgents. Someone find an example in the literature where someone was using only 1 equivalent of reagent and/or nucleophile….And don’t get me started about having to get rid of triphenylphosphine oxide and hydrazide byproducts.
You could also fill a book with examples where the reaction doesn’t work or gave an alternative product.
Study on the Synthesis of Quinoline Intermediates for Pharmacology ..
Your comments on the Skraup reaction reminded me of a grad student classmate. He tried many Skraup reactions and never had much success. He finally changed the name of the reaction from “the Skraup reaction” to “the Screw-up reaction.”
21/10/2010 · Skraup synthesis
Equation 8-3 is used to convert the frequency domain signal, (b), into theamplitudes of the cosine waves, (c). As shown, all of the cosine waves have anamplitude of , except for samples 0 and 16, which have a value of . Theamplitudes of the sine waves are not shown in this example because they havea value of zero, and therefore provide no contribution. The synthesis equation,Eq. 8-2, is then used to convert the amplitudes of the cosine waves, (b), into thetime domain signal, (a).
CHE Syllubus | Chemical Reactions | Coordination Complex
Methods for the batch scale up of DABAL-Me3 promoted direct ester to amide synthesis have been demonstrated at 10–100 g scales using a -amide model compound. Procedures for 20 g scale couplings in standard laboratory glassware and up to 0.1 kg in industry-standard jacketed glass reactors in near quantitative yields are given. A derivative of the anticancer agent Imatinib (Gleevec) has been synthesized on a 26 g scale (98% yield, >98% purity) establishing DABAL-Me3 as a potential alternative for the synthesis of amides in API scale preparations. Continuous flow methodology provides a method for larger scales (productivities of >50 g h–1). In addition, nitriles were coupled to primary amines and hydrazines with DABAL-Me3, resulting in the clean formation of free amidines (16 examples) and amidrazones.