What Antibiotics Inhibit Protein Synthesis

Cephalosporins are mainly bactericidal and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. Besides cephalosporins (which are derived from cephalosporin C) this class includes oxacephems and carbacephems.

Antibiotics - Synthesis of Best-Seller Drugs - Chapter 30

Protein Synthesis and Site of Action of Antimicrobials that Inhibit Protein Synthesis

Synthesis of Antibiotics | BCA Chemistry

Figure 2. A) Sites of action of inhibitors of bacterial protein synthesis. B) Macrolide antibiotics share a common macrocyclic lactone ring structure & deoxy sugar residues. The structures for erythromycin & clarithromycin differ only at one position (circled in green). Structures reproduced from .

Inhibition of Protein Synthesis by Antibiotics | Sigma …

mechanism, examples not producing an antisense RNA that is complementary to a mRNA, altering porins in the outer membrane of gram-negative cell walls result, producing an altered 30S or 50S ribosomal subunit to which antibiotic no longer binds example

Tetracyclines are protein synthesis inhibitors primary targeting the 30S ribosome. They are essentially bacteriostatic.

List of antibiotics - Wikipedia

mechanism altering the membranes and transport systems to prevent the entry of the antibiotic into the bacterium and/or ausing an efflux pump to transport the antibiotic out of the bacterium, action blocks active transport, enhancing the function of RNA polymerase leads to, enzymatically adding new chemical groups to aminoglycosides action, mRNA continues to be translated into enzyme leads to increased synthesis of the limited enzyme, Gene products enable the bacterium to become resistant to an antibiotic or chemical agent.

The following is a list of antibiotics

Aminoglycosides are rapidly bactericidal antibiotics which inhibit protein synthesis. These agents mainly interfere with proofreading process. Aminoglycosides are the only bactericidal class among protein synthesis inhibitors.

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Synthetic studies on polyether antibiotics

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Penicillins and cephalosporins are the major antibiotics that inhibit bacterial cell wall synthesis

50S Protein Synthesis Inhibitors

Sulfonamides act by inhibiting the pathway that bacteria use to synthesize folic acid. Sulfonamides with trimethoprim produce synergistic antibacterial activity.

Inhibition of Mammalian Mitochondrial Protein Synthesis …


Beta-lactam antibiotics are used to treat a broad spectrum of Gram-positive and Gram-negative bacteria. Beta-lactam antibiotics target the penicillin-binding proteins or PBPs – a group of enzymes found attached in the cell membrane, which are involved in the cross-linking of the bacterial cell wall. The beta-lactam ring portion of this group of antibiotics binds to these different PBPs, rendering them unable …