Amyloid Cascade Hypothesis - King's College London
Alzheimer's disease - Wikipedia, the free encyclopedia
At least 30 minutes of aerobic exercise 5 times a week
Build muscles to pump up brain
Protect your head
Diet protecting glial cells
Taking group classes
Social network system
Learn new language
Read newspaper or a book
Dull, tired, impairs ability to think, solve problems, recall information.
4-12-2006 · Alzheimer's disease ..
Amyloid-beta is formed from a large protein called amyloid precursor protein (APP). Researchers don't exactly know the function of APP yet, but it may impact the activity of brain cells. Special enzymes (called secretase) cut this protein at specific sites, and one of the products of this "cleavage" is the amyloid-beta peptide. These amyloid-beta peptides clump together into what's called oligomers, and according to the amyloid cascade hypothesis, it is these oligomers that are toxic to brain cells, causing the very early problems in Alzheimer's disease. Later, these oligomers form the that are characteristic of Alzheimer's disease, but it is the oligomers -- as opposed to the plaques -- that are the actual toxic agents.