The Amyloid Cascade Hypothesis of Alzheimer's Disease?

The most striking early symptom is loss of short term memory (), which usually manifests as minor forgetfulness that becomes steadily more pronounced with illness progression, with relative preservation of older memories. As the disorder progresses, cognitive (intellectual) impairment extends to the domains of language (), skilled movements (), recognition (), and those functions (such as and planning) closely related to the frontal and temporal lobes of the brain as they become disconnected from the , reflecting extension of the underlying pathological process. These changes make up the essential human qualities, and thus AD is sometimes described as a disease where the victims suffer the loss of qualities that define human existence.

Amyloid Cascade Hypothesis - King's College London

Solanezumab and the amyloid hypothesis for Alzheimer…

Alzheimer's disease - Wikipedia, the free encyclopedia

At least 30 minutes of aerobic exercise 5 times a week
Build muscles to pump up brain
Protect your head
Especailly good:
Coconut oil
Mediterranean diet
Diet protecting glial cells
Taking group classes
Social network system
Outdoor activites
Challenging brain
Play games
Learn new language
Read newspaper or a book
Dull, tired, impairs ability to think, solve problems, recall information.

4-12-2006 · Alzheimer's disease ..

Amyloid-beta is formed from a large protein called amyloid precursor protein (APP). Researchers don't exactly know the function of APP yet, but it may impact the activity of brain cells. Special enzymes (called secretase) cut this protein at specific sites, and one of the products of this "cleavage" is the amyloid-beta peptide. These amyloid-beta peptides clump together into what's called oligomers, and according to the amyloid cascade hypothesis, it is these oligomers that are toxic to brain cells, causing the very early problems in Alzheimer's disease. Later, these oligomers form the that are characteristic of Alzheimer's disease, but it is the oligomers -- as opposed to the plaques -- that are the actual toxic agents.

Amyloid Beta by Alexander Welch on Prezi
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