ALDOL REACTION | ADDITION | CONDENSATION | …
Aldol Reaction - Chemistry LibreTexts
Asymmetric Aldol Condensations: "Stereoselective Aldol Condensations," D. A. Evans, J. V. Nelson and T. R. Taber . 1982, , 1. "Stereoselective Alkylation Reactions of Chiral Metal Enolates," D. A. Evans in "Asymmetric Synthesis," Vol. 3, J. O. Morrison, Ed., Academic Press, 1984. "Stereoselective Aldol Condensations," C. Heathcock in "Comprehensive Carbanion Chemistry," Part B, E. Buncel, Ed. "Stereoselective Aldol Reactions with α-Unsubstituted Chiral Enolates," M. Braun, 1987, , 24. "Recent Development in Stereoselective Aldol Reactions," Braun, M. 1992, Jai Press, Greenwich, CT. "Recent Developments in Asymmetric Aldol Methodology," Franklin, A.S.; Paterson, I. 1994, , 317-38. "Catalyzed Enantioselective Aldol Additions of Latent Enolate Equivalents," Nelson, S. G. : Asymmetry 1998, , 357-89. "Asymmetric Catalysis of Aldol Reactions with Chiral Lewis Bases (Trichlorosilyl Enolates)," Denmark, S. E.; Stavenger, R. A. 2000, , 432-40. "The Catalytic Asymmetric Aldol Reaction." Machajewski, T. D.; Wong, C.-H.; Lerner, R. A. 2000, , 1352-74. "Chiral Enolate Equivalents. A Review," Spino, C. 2003, , 1-140. "Current Progress in the Asymmetric Aldol Addition Reaction," Palomo, C.; Oiarbide, M.; Garcia, J. M. 2004, , 65-75. "Memory of Chirality: Asymmetric Induction Based on the Dynamic Chirality of Enolates," Kawabata, T.; Fuji, K. 2003, , 175-205.
Aldol Condensation Reaction | Sigma-Aldrich
When the pendant substituent on the ketone is sterically large, then the enolization with lithium amides is highly stereoselective, and the aldol reaction is highly stereospecific (i.e enolate gives syn, enolate gives anti aldol product)
Aldol Condensation - Organic chemistry
Direct aldol reactions have been successfully performed using aromatic aldehyde and cyclic ketone in nonpolar solvent by using immobilized picolylamine on zirconia as a catalyst, in a double walled batch reactor. The prepared catalyst was characterized by SEM, XRD and FT-IR. FT-IR peaks reveal the presence of picolylamine on the surface of zirconia. The catalyst shows excellent catalytic activity in aldol reaction of cyclohexanone with benzaldehyde in cyclohexane giving 2-hydroxyphenylmethylcyclohexanone (55.7% yield) in 4 hr at 80˚C. Furthermore, the catalyst is recoverable by simple filtration and could be used several times without significant loss in activity.