Reacts violently with water to generate acetic acid.

of modified food starch and for acetylation of monoglyceridesAcetic anhydride is a versatile reagent for acetylations, the introduction of acetyl groups to organic substrates.

Alternative reaction conditions include using and acetic anhydride.

 IR, NMR. acetic anhydride is prepared industrially by the acylation of  with

Organic anhydrides are formed by the condensation of original acids.

The most common method for acetate introduction is the reaction of an alcohol with acetic anhydride in the presence of pyridine. Often, is used as the solvent and reactions proceed nearly quantitatively (eq 1).

Anhydrides react with alcohols to form esters; acetic anhydride [(CH

The most notable use of acetic anhydride is for the acetylation reaction of alcohols, amines, and thiols. Acids, Lewis acids, and bases have been reported to catalyze the reactions.

Comparing the reactions of acyl chlorides and acid anhydrides with these compounds

Acetic anhydride CAS 108-24-7 | 822278 - Merck Millipore

This report supplements the original Process Economics Program report on acetic acid issued in March 1968 (Report No. 37) and is expanded to include the technology and costs of three processes for the manufacture of acetic anhydride. The original report evaluated five synthetic processes for the production of acetic acid, These included: oxidation of acetaldehyde with air, oxidation of naptha, oxidation of n-butane, two-step (esterification and oxicracking) oxidation of n-butylenes, and high pressure carbonylation of methanol with carbon monoxide. The current report updates the technology and costs of these five processes and evaluates three more processes: oxidation of acetaldehyde with oxygen, direct oxidation of n-butylenes, and low pressure carbonylation of methanol with carbon monoxide. The oxygen oxidation of acetaldehyde is an old process, but it is believed that many acetic acid producers are still using it. The direct oxidation of n-butylenes, developed mainly by Chemische Werke Huls, and the low pressure carbonylation of methanol process, developed by Monsanto, were announced after the original report was issued. How- ever, most of the process details for the Monsanto process, including reaction data, actual catalyst system, and materials of construction, have not yet been published. Therefore evaluation of this process is very speculative in this report.

How to synthesize aspirin without using acetic anhydride?

Three processes for the production of acetic anhydride are evaluated in detail. The first process uses ketene produced from acetic acid, and the second process uses ketene produced from acetone; the third process is the direct oxidation of acetaldehyde. All these processes have been

Tertiary alcohols have been esterified in good yield using acetic anhydride with

in a process that is similar to the Monsanto acetic acid synthesis.

This page looks at the reactions of acid anhydrides with water, alcohols and phenols (including the manufacture of aspirin). These reactions are all considered together because their chemistry is so similar.

The reactions are slower. Acid anhydrides aren't so violently reactive as acyl chlorides.

Acetic anhydride CAS 108-24-7 | 822278

Ethanoic anhydride is safer to use than ethanoyl chloride. It is less corrosive and not so readily hydrolysed (its reaction with water is slower).

Cyclic benzylic amines may undergo ring opening upon heating with acetic anhydride (eq 9).

Sampling and Analytical Methods: Acetic Anhydride, 82

A review of other acetic acid and acetic anhydride processes described in the patent literature is also presented, together with recent information on separation and purification of acetic acid.