A Convenient Method for the Synthesis of Terminal (E)-1,3-Dienes ..

A tetracyclic anhydride, synthesized and well described by Reppe (best-known under the name of Reppe-Anhydride) turned out to be the ideal compound for our purpose 15 (Figure ). It is easily available by the classic Diels-Alder-Reaction of cyclooctatetraene (COT) 13 and maleic anhydride 14. [-] Additionally to the anhydride function this tetracyclic compound possesses a reactive double bond inside of the cyclobutene ring. The presence of a further double bond inside of the cyclohexene ring is not of relevance due to the inactivity of this double bond in the DARinv. The anhydride ring of the tetracyclic compound can be converted to the substituted corresponding imides, whereas the yield is nearly quantitative and the product can be purified easily by recrystallization (scheme/table ). Further ring systems, dedicated for chemical reactions as described above, are the cyclobutene-3,4-dicarboxylic acid anhydride [, ], as well as the commercially available and norbornen-anhydrides.

A general method for the synthesis of 1,3-dienes

It represents a general method for convenient and efficient synthesis of 1,2,4 ..

Synthesis of Highly Substituted Symmetrical 1,3-Dienes via ..

Indium-Mediated 1,2,4,5-Hexatetraen-3-ylation of 4-Acetoxy-2-azetidinones and Their Applications to the Diels-Alder Reactions for the Synthesis of 2-Azetidinone Derivatives, 2008,

for the Differential Vicinal Diarylation of Terminal 1,3-Dienes ..

Efficient Synthetic Method of Z-Selective2-Halo-1,3-dienes from Reactions of Allenols Possessing Ethoxycarbonyl and Vinyl Group with Indium Trihalide, 2010,

Kasai, et al., Novel syntheses of eight-membered-fivemembered fused-ring compounds from zirconacyclopentadienes, Organometallics 13(1994) 4183-4185.
Synthetic Method of 2-Aminomethyl-1,3-diene Derivatives Though Indium-Mediated 1,3-Butadien-2-ylation of Imines, 2009,

1,2-Amino Alcohols and Their Heterocyclic Derivatives …

Highly Selective Synthetic Method of 1,6-Diols Having Enynes: Development of 3,6-Dianion Reagent of 1,2-Hexadiene-4-yne Using 1,6-Dibromo-2,4-hexadiyne and Indium, 2007,

Sharpless, Asymmetric Dihydroxylation of Primary Alloylic Halides and a Concise Synthesis of (-)-Diepoxybutane, , 35, 3469 (1994)

General & Introductory Chemistry

Tamio Hayashi was born in Gifu, Japan, in 1948. He graduated from Kyoto University in 1970. He received his Ph.D. degree in 1975 from Kyoto University under the direction of Professor Makoto Kumada. The title of his thesis was “Catalytic Asymmetric Hydrosilylation of Olefins and Ketones”. Then he was appointed as a Research Associate in Faculty of Engineering, Kyoto University. He spent the year 1976−1977 as a postdoctoral fellow at Colorado State University with Professor Louis S. Hegedus. He was promoted to Full Professor in 1989 in the Catalysis Research Center, Hokkaido University. Since 1994, he has been Full Professor in the Faculty of Science, Kyoto University. His awards include the Award for Young Chemists of the Society of Synthetic Organic Chemistry, Japan, in 1983, the IBM (Japan) Prize in 1991, and The Chemical Society of Japan Award in 2003. He has been interested in the development of new reactions catalyzed by transition metal complexes, especially in catalytic asymmetric reactions.

Fokin, NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-beta-Lactamase: Synthesis and Structure-Activity Studies, , 1 (4), 150-154 (2010).

Microwave Assisted Synthesis of 1,5-Disubstituted ..

33. Boger DL, Panek JS. Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes - Formal Total Synthesis of Streptonigrin. 1985;107:5745-54