synthetic and antimicrobial activity of 4 thiazolidinones
synthetic and antimicrobial activity of 4 thiazolidinones.
Methods: Looking to the importance of N and S hetero cycles in the medical field, 4-thiazolidinone derivatives (3b,4b) have been synthesized by cyclization of substituted imines(1a,2a) with mercaptoacetic acid in presence of anhydrous ZnCl2 as a catalyst in DMF. The 4-thiazolidinone derivatives have also been tested against two bacterial strains viz. S. aureus and E. coli and two fungal pathogens viz. A. niger and C. albicans using Kirby-Bauer method.
Synthesis of 4-Thiazolidinone Analogs as Potent in …
Result: New series of azomethines and 4 thiazolidinones compounds have been prepared. The synthesized compounds were characterized on the basis of IR, 1H-NMR, and elemental analysis. The purity of the compounds was checked using pre coated TLC plates (MERCK) using n-hexane: ethyl acetate (8:2) solvent system. The synthesized compounds show good antimicrobial acivity.
Pd nanoparticles: an efficient catalyst for ..
General Methods of Synthesis of Thiazolidine-4-one (IVB, VB, VIB, VIIB): To a mixture of Schiff’s base (0.01mol) and thioglycolic acid (0.01mol) dissolved in 1, 4 dioxane (20ml), anhydrous zinc chloride (0.004 mol) was added and refluxed for 8h. The reaction mixture was cooled, filtered, washed with water; vacuum dried and recrystallized using absolute ethanol.
[Compounds with potential antitumor activity
SUMMARY AND CONCLUSION: The present work describes the synthesis of Schiff’s bases and their thiazolidinone derivatives along with their antibacterial activities. The Schiff bases and thiazolidine- 4- one derivatives were prepared by the method of S. Ramachandran et al. The reaction completion was confirmed by TLC and the synthesised compounds were purified by recrystallization. The structures of the synthesised compounds were assigned on the basis of the spectral data.