A series of 6-(1H-benzo[d]imidazol-2-yl)-2-(2-(3-nitrophenyl)-4-oxothiazolidin-yl)-4-(aryl)nicotinonitriles 5al were synthesized and characterized by IR, 1H NMR, 13C NMR, and mass spectrometry techniques. These novel compounds 5al were screened for their in vitro antimicrobial activity against different bacterial and fungal strains and in vitro cytotoxicity study (HeLa cell line) using MTT colorimetric assay. The results demonstrated that compounds 5c, 5e, and 5ik exhibited excellent antibacterial activity, while compounds 5d, 5i, and 5k were found to be the most potent antifungal agents. From the standpoint of SAR studies, it was observed that the presence of electron donating groups remarkably enhanced the antimicrobial activity of newly synthesized compounds. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggested that potent antimicrobial activity of 5ce and 5ik was accompanied by low cytotoxicity.

synthetic and antimicrobial activity of 4 thiazolidinones

Synthesis and Biological Activities of New Neonicotinoids Containing 4-Thiazolidinone[J].

synthetic and antimicrobial activity of 4 thiazolidinones.

Methods: Looking to the importance of N and S hetero cycles in the medical field, 4-thiazolidinone derivatives (3b,4b) have been synthesized by cyclization of substituted imines(1a,2a) with mercaptoacetic acid in presence of anhydrous ZnCl2 as a catalyst in DMF. The 4-thiazolidinone derivatives have also been tested against two bacterial strains viz. S. aureus and E. coli and two fungal pathogens viz. A. niger and C. albicans using Kirby-Bauer method.

Synthesis of 4-Thiazolidinone Analogs as Potent in …

Result: New series of azomethines and 4 thiazolidinones compounds have been prepared. The synthesized compounds were characterized on the basis of IR, 1H-NMR, and elemental analysis. The purity of the compounds was checked using pre coated TLC plates (MERCK) using n-hexane: ethyl acetate (8:2) solvent system. The synthesized compounds show good antimicrobial acivity.

Pd nanoparticles: an efficient catalyst for ..

General Methods of Synthesis of Thiazolidine-4-one (IVB, VB, VIB, VIIB): To a mixture of Schiff’s base (0.01mol) and thioglycolic acid (0.01mol) dissolved in 1, 4 dioxane (20ml), anhydrous zinc chloride (0.004 mol) was added and refluxed for 8h. The reaction mixture was cooled, filtered, washed with water; vacuum dried and recrystallized using absolute ethanol.

[Compounds with potential antitumor activity

SUMMARY AND CONCLUSION: The present work describes the synthesis of Schiff’s bases and their thiazolidinone derivatives along with their antibacterial activities. The Schiff bases and thiazolidine- 4- one derivatives were prepared by the method of S. Ramachandran et al. The reaction completion was confirmed by TLC and the synthesised compounds were purified by recrystallization. The structures of the synthesised compounds were assigned on the basis of the spectral data.

4-Thiazolidinone Derivatives as MMP Inhibitors in …

Mahendra R. Shriadkar, Mangesh Ghodake, Kailash G. Bothara, Synthesis and Anticonvulsant activity of clubbed thiazolidinone-barbituric acid and thiazolidinone-triazole derivatives. ARKIVOC, 2007:58-74.

Synthesis and Characterization of the Thiazolidinone …

2-(4-Chloro-3-methylphenoxy)acetohydrazide (51)derived from ethyl 2-(4-chloro-3-methylphenoxy) acetate (50) was reacted with different aromatic aldehydes to yield N-(substituted benzylidiene)-2-(4-chloro-3-methylphenoxy)acetamide (52a-e). Cyclization of compound (52a-e) with thioglycolic acid yielded 2-(4-chloro- 3-methylphenoxy)-N-(4-oxo-2-arylthiazolidin-3-yl) acetamide (53 a-e). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities. Neeraj et al, 2009 [].

2-Thioxo-4-thiazolidinone CAS 141-84-4 | 821063

Velmurugan, V, Leelavathi. N, Kalvikkarasi. S, Synthesis and anticonvulsant activity of thiazolidinone derivatives. Int. j. ChemTech Res 2012;Vol.4, No.1;01-04.